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Synthesis and biological activity of some ring-substituted tryptamiries

, : Synthesis and biological activity of some ring-substituted tryptamiries. J Med Chem 10(4): 646-648

The synthesis of tryptamines having a hydroxy, methoxy, or benzyloxy substituent in the 5, 6, or 7 positions is reported. Eight of the 9 compounds examined showed activity in modifying the open-field behavior of rats. With 2 exceptions all of the compounds evoked a hyperthermia in rabbits; the more active compounds in this respect were also lethal to rabbits. Substitution in the 5 position of the indole nucleus conferred higher biological activity than did substitution by the same group in either the 6 or 7 positions.


PMID: 4962512

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