+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synthesis of cis- and trans-2-phenoxycyclopropylamines and related compounds

, : Synthesis of cis- and trans-2-phenoxycyclopropylamines and related compounds. Journal of Medicinal Chemistry 8(4): 432-439

In continuing the study of mono-amine oxidase MAO inhibitors in these laboratories, the 2-phenoxycyclo-propylamines were synthesized and found to be potent compounds. From the various intermediates, derivatives were prepared to explore their biological potentials. Also, several substituted aryloxycyclopropylamines were synthesized to determine the relationship between chemical constitution and pharmacological activity.


PMID: 5884163

DOI: 10.1021/jm00328a005

Other references

Shellikeri, S.; Karthikeyan, V.; Martino, R.; Black, S.E.; Zinman, L.; Keith, J.; Yunusova, Y., 2017: The neuropathological signature of bulbar-onset ALS: A systematic review. ALS is a multisystem disorder affecting motor and cognitive functions. Bulbar-onset ALS (bALS) may be preferentially associated with cognitive and language impairments, compared with spinal-onset ALS (sALS), stemming from a potentially unique neur...

Pal, R.; Mamidi, M.Krishna.; Das, A.Kumar.; Bhonde, R., 2011: Human embryonic stem cell proliferation and differentiation as parameters to evaluate developmental toxicity. In vitro models based on embryonic stem cells (ESC) are highly promising for improvement of predictive toxicology screening in humans. After the successful validation of embryonic stem cell test (EST) in 2001; concerns have been raised on the usag...

Jahn, Theodore L., 1960: Ciliary reversal and activation by electric current; the Ludloff phenomenon in terms of core and volume conductors. Abstract.

Houghton, R.A., 1993: Is carbon accumulating in the northern temperate zone?. The current imbalance in the global carbon budget ("missing carbon") is approximately 1.5 to 2.0 PgC/yr. The study by Tans et al. (1990), based on geographically based estimates of industrial emissions, atmospheric data, and a model of a...

Que, L.; Gray, G.R., 1974: 13C nuclear magnetic resonance spectra and the tautomeric equilibria of ketohexoses in solution. Biochemistry 13(1): 146-153

Amin, S.Abdul.Wanees.; Seyam, R.Saeed.; El-Samman, M.Abbas., 2012: The effect of prior calcium hydroxide intracanal placement on the bond strength of two calcium silicate-based and an epoxy resin-based endodontic sealer. The aim of this study was to investigate the effect of prior calcium hydroxide (Ca[OH](2)) intracanal placement on the bond strength of AH Plus (Dentsply DeTrey GmbH, Konstanz, Germany), iRoot SP (Innovative Bioceramix, Vancouver, BC, Canada), and...

Lu, W.; Zhao, X.; Xu, Z.; Dong, N.; Zou, S.; Shen, X.; Huang, J., 2014: Development of a new colorimetric assay for lipoxygenase activity. Lipoxygenases (LOXs) are a family of non-heme iron-containing dioxygenases that catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. A rapid and reliable colorimetric assay for determination of the activity of t...

García Irigoyen, C.; Benítez Reyes, F.S.; Granados Márquez, R.; Aranalde Blanco, J.; Romero Flores, F., 1978: Prostatic-vesical rhabdomyosarcoma. Boletin Medico del Hospital Infantil de Mexico 35(5): 879-896

Wolf, H.Trap.; Wulff, C.Bernt.; Ekelund, C.; Sundberg, K.; Tabor, A., 2016: Characteristics of first-trimester screening of non-responders in a high-uptake population. Our aim was to compare demographic, social and reproductive health-related medical factors between women who did and women who did not undergo combined first-trimester screening (cFTS) and to examine their reasons for declining a screening offer,...

Laval Martin, D.; Dubertret, G.; Calvayrac, R., 1977: Photosynthetic properties of a DCMU resistant strain of Euglena gracilis Z. Diuron at concns. of about 10-9 to 10-6M induced significant loss of chlorophyll and disorganization of chloroplast structure as well as inhibiting photosynthetic electron transport in Euglena gracilis cultures. However, after 2 months under these...