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Synthesis of protein and regulation processes in the cell

, : Synthesis of protein and regulation processes in the cell. Arkh Anat Gistol Embriol 50(5): 3-13

Data on protein synthesis in the cells of the guinea pig, rat and mouse obtained by autoradiography were summarized. The method of estimating a rate of renewal of protein, worked out in the Leblond's laboratory, enabled the investigators to reveal the synthesis of the 2 types of proteins[long dash]quickly renewing and slowly renewing[long dash]in the acinar cells, nerve cells, retinal rods, cells of the thyroid gland. A rapidly renewing protein which is a functional one, is synthesized in the zones of well developed ergastoplasm and is transferred along neurone or into the apical part of the acinar cell. The rate of the synthesis of transfer and expenditure of functional protein reveals the autoregulation process in the normal cell. A steady state is, apparently, maintained at different structural levels of the cell. It may be suggested that the rate of protein synthesis on ribosomes plays an important role in this regulation.


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