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Testosterone propionate and histamine metabolism in rats


, : Testosterone propionate and histamine metabolism in rats. American Journal of Physiology 201: 740-742

Urinary histamine output has been studied under various experimental conditions in rats. Orchidectomy increased the output of free histamine in rats of the Sprague-Dawley strain but not in rats of the Wistar strain. Subcutaneous administration of testerone propionate (I mg/rat) suppressed the output of free histamine in ovari-ectomized rats but not in normal females, which showed the effect only after repeated administration of this hormone. When exogenous histamine (100 [mu]g) was administered at a constant rate over a 4-hr peroid, only a minute quantity of administered histamine appeared as free histamine in the urine of male rats. In contrast, 23% of administered histamine appeared as free histamine in the urine of female rats. When repeatedly treated with testosterone, female rats eliminated exogenous histamine more like males. The close relationship between testosterone and histamine metabolism in rats is thus clearly demonstrated.

US$29.90

PMID: 14455970


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