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The 17-ketosteroid/17-hydroxycorticosteroid ratio as a useful measure of the physiological age of the human adrenal cortex

, : The 17-ketosteroid/17-hydroxycorticosteroid ratio as a useful measure of the physiological age of the human adrenal cortex. Journal of Gerontology 21(1): 112-114

The rates of excretion of 17-ketosteroids and 17-hydroxycorticosteroids were determined in 284 ambulatory, healthy men ranging in age from 17 through 88 years. It was found that the ratio of these 2 groups of hormones significantly declined with increasing age. This ratio apparently can be used as a measure of the physiological age of the human adrenal cortex. It was also ascertained that this ratio showed a diurnal variation with the maximum during the overnight period of excretion and the minimum during the morning. From this and other considerations discussed, the hypothesis is supported that this ratio has a direct physiological significance.


PMID: 5901650

DOI: 10.1093/geronj/21.1.112

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