geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The 17-ketosteroid/17-hydroxycorticosteroid ratio as a useful measure of the physiological age of the human adrenal cortex


, : The 17-ketosteroid/17-hydroxycorticosteroid ratio as a useful measure of the physiological age of the human adrenal cortex. Journal of Gerontology 21(1): 112-114

The rates of excretion of 17-ketosteroids and 17-hydroxycorticosteroids were determined in 284 ambulatory, healthy men ranging in age from 17 through 88 years. It was found that the ratio of these 2 groups of hormones significantly declined with increasing age. This ratio apparently can be used as a measure of the physiological age of the human adrenal cortex. It was also ascertained that this ratio showed a diurnal variation with the maximum during the overnight period of excretion and the minimum during the morning. From this and other considerations discussed, the hypothesis is supported that this ratio has a direct physiological significance.

US$19.90

PMID: 5901650

DOI: 10.1093/geronj/21.1.112


Other references

Cassi E.; D.P.oli A.; Tosi A.; Turri C., 1985: Pure osteolytic lesions in myelofibrosis 2 cases. Haematologica 70(2): 178-183

Martínez-Subiela, S.; García-Martínez, J.D.; Tvarijonaviciute, A.; Tecles, F.; Caldin, M.; Bernal, L.J.; Cerón, J.J., 2014: Urinary C reactive protein levels in dogs with leishmaniasis at different stages of renal damage. The objectives of the study were to validate a time-resolved immunofluorometric assay for C reactive protein (CRP) quantification in urine of dogs and to investigate the influence that the presence of proteinuria and azotemia could have on serum a...

Kondratov L.S.; Yershova M.V., 1986: Natural gas in rocks with respect to exploration of useful deposits. Izvestiya Vysshikh Uchebnykh Zavedeniy: giya i Razvedka. 1986; 7, Pages 123-126. 1986.

Oka, M.; Angrist, A., 1963: Histochemical study of platelets in cardiac valvular vegetations and mural thrombi. Amer Jour Clin Pathol 39(3): 299

Craig A.S.; Parker D.; Adams H.; Bailey N.A., 1989: Stability gallium 71 nmr and crystal structure of a neutral gallium iii complex of 1 4 7 triazacyclononanetriacetate a potential radiopharmaceutical. Journal of the Chemical Society Chemical Communications (23): 1793-1794

Haard J.; Ulfgren A C.; Ahlstedt S.; Matsson P., 1988: Surface characterization if ige binding cells in peripheral blood assessed by flow cytometry and sorting. Journal of Allergy & Clinical Immunology 81(1): 304

Phillips, R.W., 1955: Reversal of renal insufficiency in gout; report of a case treated with probenecid (benemid). A.M.A. Archives of Internal Medicine 96(6): 823-827

Virenque, J.; Gaubert, J., 1964: Remarks Apropos Of 15 Observations Of Sympathoblastomas In Infants. Annales de Chirurgie 18: 1390-1401

Arce J.M.; Naughton B.A.; Kolks G.A.; Liu P.; Gordon A.S.; Piliero S.J., 1981: The effect of prostaglandin a 2 prostaglandin e 1 prostaglandin e 2 15 methyl prostaglandin e 2 16 16 di methyl prostaglandin e 2 and 16 16 di methyl prostaglandin f 2 alpha on erythropoiesis. Prostaglandin [PG] A2 PGE1, PGE2, methylated PGE2 and PGF2.alpha. affected erythropoiesis and/or erythropoietin (Ep) production. This action is indicated in the exhypoxic, polycythemic mouse where radioiron incorporations into red blood cells incr...

Iliff, Marshall., 1996: Spring season. March 1 - May 31, 1996. Mid-Atlantic Region. National Audubon Society Field Notes. Fall; 503: 262-266