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The Effect Of Carotid Occlusion And Central Vagal Stimulation On The Free Fatty Acids Of Plasma And The Blood Pressure In The Dog


, : The Effect Of Carotid Occlusion And Central Vagal Stimulation On The Free Fatty Acids Of Plasma And The Blood Pressure In The Dog. Acta Medica Scandinavica 176: 65-71

The possible role of baroceptor reflexes in the mobilization of free fatty acids [FFA] of plasma was studied in the dog by means of carotid occlusion and central vagal stimulation. Carotid occlusion and central vagal stimulation produced a marked rise in the mean blood pressure during 2 30-minute periods. The mean plasma concentration of FFA increased only slightly, but significantly, from 0.33 to 0.46 mEq/1 and from 0.37 to 0.47 mEq/1 during the 2 periods of carotid occlusion respectively. When the central ends of the cut vagus nerves were stimulated, the plasma FFA concentration was unchanged. To reproduce the effect of carotid occlusion and central vagal stimulation on the blood pressure, doses of norepineph-rine and epinephrine were infused intravenously. The requisite doses caused an almost 10-fold rise of the plasma FFA concentration. The results suggested that vasoconstrictor nerves can be activated by means of baroceptor reflexes without any major mobilization of FFA in dogs.

US$19.90

PMID: 14194192

DOI: 10.1111/j.0954-6820.1964.tb00646.x


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