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The effect of cations on ammonia accumulation in brain cortex slices

, : The effect of cations on ammonia accumulation in brain cortex slices. Journal of Neurochemistry 4: 304-310

In the presence of exogenous substrate (glucose) the presence of 30 meq/1 K+ in aerobic conditions lowered the ammonia concentration from 7.5 to 1.5 /[mu]moles/g slice. Increasing the K+ concentration above 30 meq/l increased ammonia production; Rb+ and Li+ had a similar effect. To some extent the K+ effect was antagonized by Ca++. 2,4-Dinitrophenol (5 x 10-4 [image]) and anaerobiosis increased ammonia formation by cortex slices in the presence of glucose.


PMID: 14440446

DOI: 10.1111/j.1471-4159.1959.tb13209.x

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