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The effect of drugs on vibration tolerance

, : The effect of drugs on vibration tolerance. Archives Internationales de Pharmacodynamie et de Therapie 155(2): 289-299

Male mice were subjected to whole-body mechanical vibration at [plus or minus] 10 g and 25 cps to the point of death. The LT 50 (vibration time required to kill 50% of mice) was 20. 24 min. Mice vibrated for 20. 25 min. were pretreated with various drugs. Vibration tolerance was increased significantly by chlordiazepoxide, reserpine, pento barbital and phenobarbital. Some degree of protection was found with hydroxyzine, chlorpromazine and meprobamate. Mephenesin was without effect on vibration tolerance, while vibration mortality was significantly increased by morphine, iproniazid, dextroamphetamine and phenoxybenzamine. It is suggested that, although the lethal effects of vibration in mice are due in large part to mechanical oscillatory displacement of viscera and to intrapulmonary pressure gradients, there may also be central nervous system changes contributing to vibration mortality which are suppressed by central depressant, and enhanced by central stimulant, drugs.


PMID: 5841186

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