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The effect of exhaustion on the permeability of the blood-brain barrier


, : The effect of exhaustion on the permeability of the blood-brain barrier. Dokl Akad Nauk Sssr 150(5): 1171-1173

Rats were exhausted by electrical stimulation of a weight-bearing extremity; 30 minutes before decapitation they were injected with 5 [mu]Cu. of I131 and comparisons were made later of the radioactivity (number of counts) per 100 mg between the blood and brain tissue. In exhausted rats the radioactivity of the brain was 5. 5[plus or minus]0. 5% of that of the blood; in controls it was 2. 7[plus or minus]0. 3%. Of 40 mice exhausted by swimming, 30 went into convulsions caused by penetration into the central nervous system of intraperitoneally injected acid fuchsin, as compared to only 7 of 40 controls; time from injection to onset of convulsions averaged 53 minutes in exhausted mice and 171 minutes in controls. When serum of blood taken from controls and from cats exhausted by electrical stimulation was injected into other cats via the internal carotid artery or directly into the brain, changes induced in the vasomotor reflexes showed differences in the penetration of physiologically active substances through the blood-brain barrier. All these changes in the blood-brain barrier upset both the defensive and regulatory functions of it by allowing penetration into the brain of substances which do not occur naturally in the body and of metabolic products which enter the blood from the tissues on exhaustion.

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