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The Effect Of Hydrochlorothiazide On The Conditioned Reflex In Dogs

, : The Effect Of Hydrochlorothiazide On The Conditioned Reflex In Dogs. Sheng Li Xue Bao 27: 298-302

The effects of HCT alone and in combination with KC1 or NaCl on the salivary conditioned reflex, blood pressure and levels of serum K and Na were studied in 5 dogs. During the oral administration of HCT at doses of 10, 20 and 50 mg/kg/day in a period of 5[long dash]10 days, the conditioned reflexes diminished significantly, the latent periods were prolonged, the differentiated conditioned reflex was disturbed in 1 dog, and phase conditions were observed in some experiments. The unconditioned reflex was either unaltered or depressed less prominently than the conditioned reflexes. HCT at 50 mg/kg/day decreased the blood pressure of 1 renal hypertensive dog, but had no effect on normal blood pressure. At 10 mg/kg/day it produced a significant decrease of the conditioned reflex, while the blood pressure remained unchanged, When NaCl or KC1 was given per os in conjunction with HCT, the effect on blood pressure disappeared, whereas the change of the conditioned reflex remained. The mode of action of HCT on the conditioned reflexes differs from that on the cardiovascular system.


PMID: 14235946

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