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The hyperglycemic effect of tyrosine and of methionine in the rat


, : The hyperglycemic effect of tyrosine and of methionine in the rat. Compt Rend Soc Biol 144(11/12): 837-839

Exptl. hyperglycemia in the rat produced by a diet rich in tyrosine (5-10%) is reversible: reduction of tyrosine leads to a return of the glycemia to the normal level. Admn. of methionine in addition to tyrosine does not cause disappearance of the hyperglycemia, but, on the contrary, accentuates it. Furthermore, addition of a diet based on methionine alone (5%) leads to a hyperglycemia comparable to that obtained with tyrosine and likewise reversible. The authors discuss the possible explanations of the phenomenon and discard the production of tyramine, the irreversible destruction of Langerhans islets, the blockage of the tyrosinic OH of insulin,and favor the hypothesis of a hyper-production of epinephrine, the tyrosine leading to the formation of dopa and the methionine to an increased methylation of the norepinephrine.

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