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The hypocretins as sensors for metabolism and arousal

, : The hypocretins as sensors for metabolism and arousal. Journal of Physiology 587(1): 33-40

Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours.


PMID: 19047201

DOI: 10.1113/jphysiol.2008.164400

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