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The influence of certain ointment bases on the cutaneous absorption of potassium iodide and of Iothion, an organic iodine compound


, : The influence of certain ointment bases on the cutaneous absorption of potassium iodide and of Iothion, an organic iodine compound. Dermatologica [basel] 115(4): 530-533

The influence of various ointment bases (petrolatum, lard, polyethyleneglycol, lanolin, emulsions of water in oil and oil in water, stearyl alcohol, vaseline) on the cutaneous absorption of KI and Iothion were studied by determination of I excreted in the urine. KI is highly soluble in water, practically insoluble in fats, and contains I in ionized form. Iothion (l-3-diiodo-2-propanol) is relatively insoluble in water and extremely soluble in fatty compounds. Experiments with KI were negative. Best resorption of Iothion was obtained when petrolatum was used, with emulsion oil in water, lanolin, lard, and polyethyleneglycol following in decreasing order.

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