+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The Influence Of Drug-Tissue Interactions On The Inhibition Of Monoamine Oxidase By Pheniprazine And Iproniazid

, : The Influence Of Drug-Tissue Interactions On The Inhibition Of Monoamine Oxidase By Pheniprazine And Iproniazid. Journal of Pharmacology and Experimental Therapeutics 142: 141-146

The anti-monoamine oxidase (MAO) properties of pheniprazine (PIH) and iproniazid in the supernatant fractions of homogenates exposed to the inhibitors were investigated. In the in vitro experiments it was shown that PIH disappeared rapidly from the supernatant fluid of brain homogenate . This effect was apparently nonenzymic, for boiled brain homogenate was even more active in inactivating PIH. Liver tissue was also effective but to a lesser degree. The disappearance of active PIH from the supernatant correlated well with the rapid onset of peak inhibition produced by this compound. Iproniazid disappearance was not evident with low concentrations of tissues, but with larger amounts of liver homogenate, an early loss of MAO inhibitory activity was seen in the supernatant fraction. This was followed by a sudden increase in inhibitor activity and was maintained throughout the experimental period. Concomitant assay of the enzyme indicated a progressively increasing inhibition of the MAO which reached maximum after 2 hours of preincubation with the inhibitor. The supernatant MAO inhibitory activity of brain and liver homogenates prepared from rats pretreated with PIH disappeared rapidly, and within 60 minutes detectable amounts were essentially absent. In iproniazid pretreated animals supernatant MAO inhibitory activity persisted for 12 to 18 hours after drug administration, although peak levels occurred some 1 to 2 hours after injection. The rate of disappearance of PIH and iproniazid activity from the supernatant probably is associated with the time of onset of peak activity of the 2 compounds, under both in vitro and in vivo conditions.


PMID: 14085495

Other references

Anonymous, 1920: VILLAGE TUBERCULOSIS SETTLEMENTS: Deputation to the Minister of Health. British Medical Journal 1(3092): 476-476

Spiga, F.; Liu, Y.; Aguilera, G.; Lightman, S.L., 2011: Temporal effect of adrenocorticotrophic hormone on adrenal glucocorticoid steroidogenesis: involvement of the transducer of regulated cyclic AMP-response element-binding protein activity. The availability of active steroidogenic acute regulatory protein (StAR) and side-chain cleavage cytochrome P450 (P450scc) are rate-limiting steps for steroidogenesis. Transcription of StAR and P450scc genes depends on cyclic AMP-response element-...

Akindahunsi, A.A.; Oboh, G., 2003: Effect of fungi fermentation on organoleptic properties, energy content and in-vitro multienzyme digestibility of cassava products (flour & gari). In this study, the fungi fermented cassava products (gari and flour) were produced by fermenting cassava mash with pure strains of some common saprophytes, namely, Aspergillus flavus, Aspergillus niger, Rhizopus oryzae, and Saccharomyces spp. (Bak...

Carlisle, D., 1989: Combating violence. Nursing Times 85(42): 18-18

Paira, R.; Anwar, T.; Banerjee, M.; Bharitkar, Y.P.; Mondal, S.; Kundu, S.; Hazra, A.; Maulik, P.R.; Mondal, N.B., 2014: Copper-phenanthroline catalysts for regioselective synthesis of pyrrolo[3',4':3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines and of pyrrolo[1,2-a]phenanthrolines under mild conditions. A new series of pyrrolo[3',4':3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines and pyrrolo[1,2-a]phenanthrolines were efficiently built up from an 8-hydroxyquinoline derivative or phenanthroline via 1,3-dipolar cycloaddition reaction inv...

Barnes, K.M., 1987: The nurse workforce: health care's most important human resource. Florida Nurse 35(8): 6-6

Dudley-Cash, Wa, 1991: Research on stunting syndrome in turkeys examines causative agents. Feedstuffs 63(26): 12-13

Nilan, R.A.; Konzak, C.F., 1961: Increasing the efficiency of mutation induction. Considerable progress has been made in recent years in increasing the efficiency of mutation induction by radiation in seeds. Certain chemical mutagens, such as diethyl sulfate and ethyl methane sulfonate, may be more efficient than radiation in c...

Nitzberg, D.M., 1971: The basic neighborhood health center data system. American Journal of Public Health 61(10): 2065-2084

Ponomarenko, N.A.; Aleksandrova, E.S.; Vorobiev, I.I.; Durova, O.M.; Kozyr, A.V.; Kolesnikov, A.V.; Telegin, G.B.; Kalinina, A.R.; Suchkov, S.V.; Gabibov, A.G., 2001: Natural antibody catalytic activities in mice with autoimmune disorders. Doklady Biochemistry 375: 224-227