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The pharmacology of the new cardiac glycoside erysimosol The pharmacology and pharmaco-therapy of the alkaloids and glycosides


, : The pharmacology of the new cardiac glycoside erysimosol The pharmacology and pharmaco-therapy of the alkaloids and glycosides. The pharmacology of the new cardiac glycoside erysimosol The pharmacology and pharmaco-therapy of the alkaloids and glycosides K farmakologii novogo serdechnogo glikozida erizimozola In: Farmakologiya i farmakoterapiya alkaloidov i glikozidov The pharmacology and pharmaco-therapy of the alkaloids and glycosides 70-73

Erysimosol (I) was produced by reduction of erysimosid and was found as an ac-companing substance in the seeds of Strophanthus kombe and in all the species of Erysimum studied. According to its chemical structure, it belongs to the diglycosides. The biological activity of I was determined in cats, frogs, and pigeons. One g of I contains 67,708 frog units, 10,121 cat units, and 18,820 pigeon units: thus its biological activity resembles that of erysimin, erysimoside, and olitoriside. Experiments on cats showed that I acts selectively on the heart. At low dosages it exerts quieting action on the central nervous system, but at high dosages it causes excitement. The maximum tolerated dosage was 0.04 mg/kg, the least toxic dosage 0.05 mg/kg, the minimum LD 0.12 mg/kg. I decomposed quickly in the gastrointestinal tract. Its enteral coefficient is about that of K-strophanthin. The cumulative properties of I were also studied in cats given 40% of the minimum LD intravenous and determination were made of the cumulated residue of the preparation in these animals in 24 hours and 3 days. It was noted that the cumulated residue of I in 24 hours was 28.2%, in 3 days 5.5%, i.e. the preparation is almost completely excreted from the body.

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