geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Toxic and therapeutic response of blood and bone marrow to sulfanilamide


, : Toxic and therapeutic response of blood and bone marrow to sulfanilamide. Proc Soc Exp Biol And Med 43(1): 29-32

After administration of therapeutic doses of sulfanilamide to a group of 9 patients, an increase in the mean corpuscular vol. of the erythrocytes and a moderate reduction in the total erythrocyte count were observed. The Hb, leucocytes, reticulocytes and icterus index were not markedly altered. The sternal bone-marrow showed a moderate normoblastic hyperplasia with most of these cells at the orthochromatic stage. The toxic effect of sulfanilamide was noted in one case. This was manifested by a marked depression of the Hb and erythrocyte count, pronounced leucocytosis, macro-cytosis, reticulocytosis and elevated icterus index. The bone-marrow revealed a marked normoblastic and pronormoblastic reaction with most of the normoblasts of the basophilic type.

US$19.90

DOI: 10.3181/00379727-43-11084


Other references

Langen, R.C.; Schols, A.M.; Kelders, M.C.; Wouters, E.F.; Janssen-Heininger, Y.M., 2001: Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. Muscle wasting is often associated with chronic inflammation. Because tumor necrosis factor a (TNF-a) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined. TNF-a activated nuclear factor-kB (NF-kB) and i...

Maloney, Tm, 1985: Utilization of lodgepole pine forest and forest products residuals for composition board. Lodgepole pine the species and its management: symposium proceedings May 8-10-1984 Spokane Washington USA repeated May 14-16-1984 Vancouver British Columbia Canada comp ed by DM Baumgartner et al: 330

Kshitij Thorat, 2011: Radio-Optical Imaging of ATLBS Survey. We present the radio-optical imaging of ATLBS, a sensitive radio survey (Subrahmanyan <i>et al.</i> 21). The primary aim of the ATLBS survey is to image low-power radio sources which form the bulk of the radio source population to mode...

Xu, R.; Yokoyama, W.H.; Irving, D.; Rein, D.; Walzem, R.L.; German, J.B.uce, 1998: Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. Male golden Syrian hamsters were fed for 16 weeks on a hypercholesterolemic diet containing, per kg, 150 g of lipids (90 g butterfat, 35 g vitamin E-stripped corn oil and 25 g fish oil), 2 g cholesterol and either 3 IU vitamin E (3 IU E), 3 IU vit...

Stijn Dhondt; Carolien Beckx; Bart Degraeuwe; Wouter Lefebvre; Bruno Kochan; Tom Bellemans; Luc Int Panis; Cathy Macharis; Koen Putman, 2012: Health impact assessment of air pollution using a dynamic exposure profile Implications for exposure and health impact estimates. In both ambient air pollution epidemiology and health impact assessment an accurate assessment of the population exposure is crucial. Although considerable advances have been made in assessing human exposure outdoors, the assessments often do not...

Shimizu Y., 1981: Function test of chorionic villi electrophoresis. Acta Obstetrica Et Gynaecologica Japonica (japanese Edition): 2363

Buss D.; Leopold D.; Smith A.P.; Routledge P.A., 1983: Determinants of the plasma protein binding of theophylline in health. The plasma protein binding of theophylline was determined after addition of [14C]-theophylline (15 .mu.g/ml) to plasma from 24 healthy drug-free volunteers and equilibrium dialysis for 2 h at 37.degree. C. The percentage of drug unbound was 60.0%...

Ivanov, V.G., 1976: Enteropathogenic types of E. coli in mixed feeds. Veterinariia: 21-22

Dentali, F.; Donadini, M.; Gianni, M.; Bertolini, A.; Squizzato, A.; Venco, A.; Ageno, W., 2009: Incidence of chronic pulmonary hypertension in patients with previous pulmonary embolism. The true incidence of chronic thromboembolic pulmonary hypertension (CTPH) remains a matter of debate. Symptomatic CTPH is probably more common than previously reported, whereas the occurrence of asymptomatic CTPH has not been defined since very l...

Looney, A.T.; Nason, G.J.; McGuire, B.B.; Kelly, M.E.; Mulvin, D.W.; Galvin, D.J.; Quinlan, D.M.; Lennon, G.M., 2016: Incidentalology: A developing urological sub-specialty. To identify the incidence and features of significant incidental findings discussed at our departmental multidisciplinary team meeting (MDM). The improved quality of radiological imaging has resulted in increased rates of incidental findings. Alth...