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Transformation of African green monkey kidney cells by irradiated adenovirus 7-simian virus 40 hybrid


, : Transformation of African green monkey kidney cells by irradiated adenovirus 7-simian virus 40 hybrid. Journal of Virology 2(3): 173-177

The ability of adenovirus 7-simian virus 40 (SV40) hybrid (strain LL "E-46") to replicate decreased exponentially as a function of the amount of [gamma]- irradiation; the ability to induce SV 40 and adenovirus 7 T antigen decreased at a much slower rate. Nevertheless, the virus was still able to transform African green monkey kidney cells at a radiation dosage that had completely destroyed its replication ability. All transformed colonies were positive for SV40 T antigen but were negative for adenovirus 7 T antigen. The adenovirus 7-SV 40 hybrid transformed cells were superinfectible with SV40 virus. Two of the 3 transformed cell populations apparently did not sensitize hamsters against the appearance of Sv40 primary tumors, thus suggesting a deficiency in the SV40 transplantation antigen.

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PMID: 4316019


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