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Treatment of advanced mammary cancer with 3 , 17 -androstanediol

, : Treatment of advanced mammary cancer with 3 , 17 -androstanediol. Cancer 13(6): 1195-1200

A double blind study of 3[beta], 17[beta]-androstanediol versus testosterone propionate in 44 patients with disseminated breast cancer, resulted in 3 regressions, (14%), on the former drug and 2 regressions (9%), on the latter. All were postmenopausal women with no previous hormone therapy. Dosage was 100 mg intramuscular 3 times weekly. Masculinization on 3[beta], 17[beta]-androstanediol was limited primarily to mild hirsutism and voice change. It did not appear to depress gonadotropins. This study supports the belief that 3[beta], 17[beta]-androstanediol is another effective androgen against breast carcinoma with less masculinizing side effects than the standard testosterone propionate.


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