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Treatment of chronic fatigue with adenosine triphosphate


, : Treatment of chronic fatigue with adenosine triphosphate. Presse Med 66(55): 1265-1268

Fatigue is described as being a minor response of the major correlative systems (central and autonomic nervous systems and endocrines) to repeated assault as opposed to the major response (shock) concept. This response is divided into stages: (1) harmonious response (physiologic fatigue), (2) oscillating response, (3) discordant response (functional adrenal insufficiency), (4) phase of exhaustion (polyendocrine involvement). The last 2 stages correspond to pathologic fatigue; stage 2 is intermediate between acute and chronic fatigue. Forty-five subjects with symptoms of stages 3 and 4 were treated with adenosine triphosphate (ATP) in a dose of 20 mg intramuscularly for 20 to 40 days followed by 24 to 26 mg orally for 2 to 5 months. The subjects in stage 3 showed: (1) an improvement in their general condition, (2) increase in weight (average of 1500 kg), (3) normalization of arterial pressure (4) improved mental state. The excretion of 17-ketosteroids increased from 8.7 to 10.5 mg and 17-hydroxycorticoids from 3.3 mg to 3.9 mg. ATP exerted a favorable * action on the 17-hydroxylation of corticosterone as evidenced by the return to normal of the ratio in the urine of cortisol metabolities to corticosteroid metabolites. Negative K balance and glucose metabolism returned to normal. Excitation of muscle by electrical stimulation, diminished in 45% of cases, was reestablished. Subjects in stage 4 (polyendocrine involvement with total or partial pituitary deficiency) benefited from ATP treatment only when they were given ACTH treat-ment, which placed them in stage 3, previous to the ATP.

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