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Uber Neodorm


, : Uber Neodorm. Zeitschr Ges Exp Med 73(5/6): 586-598

For white mice (46 mice) the minimal lethal dose per kgm. subcut. is for neodorm, 0.265 gm.; for chloral hydrate, 0.42 gm.; for ethyl alcohol, 825 gm.; therefore, on the mouse, neodorm is 1.6 times more active than chloral hydrate and 30.6 times more active than ethyl alcohol. The m.l.d. of neodorm for the frog after injection into the lymph sac lies between 0.1 and 0.33 mgm. per gm. For (255) salamander larvae, the fatal conc. of neodorm is 1: 700; for chloral hydrate, 1:100; for ethyl alcohol, 1:20. The paralyzing concentration of neodorm (for salamander larvae) is 1:26000; of chloral hydrate, 1:750; of ethyl alcohol, 1: 90. The just effective concentration of neodorm (for salamander larvae) is 1:50000; of chloral hydrate, 1:1000; of ethyl alcohol, 1:200. From these figures, it is obvious that neodorm has a marked "therapeutic breadth"; (paralyzing-fatal threshold concentration quotient) 4 times greater than chloral hydrate and 8 times that of ethyl alcohol. In comparison to chloral hydrate and ethyl alcohol the "total activity breadth" (just effective-fatal concentration threshold quotient) of neodorm is 7-fold. Distinct signs of excitement which may culminate in convulsions; occur in the mouse after neodorm, in the amphibian larvae, excitement was not observed; on frogs, seldom. In the mouse during the hypnotic stage, the respiration is at first slowed but deepened; dyspnea occurs later; and, after lethal doses, cessation of respiration. On all types of animals used, the influence of neodorm on the circulation, especially the heart, is very slight. On isolated frog organs (skeletal muscle (52) ; motor nerve and heart (61)) neodorm has greater absolute activity than chloral hydrate and ethyl alcohol; but, in comparison to narcotic action on the central nervous system, has so little effect that, practically, "side actions" on these organs, especially the heart, scarcely come into consideration. The cardiac action of neodorm (reduction of systole; after larger doses, diastolic stand-still) is easily reversible; the neodorm stoppage of the heart can not only be quickly and completely overcome by Ringer's sol., but, after more prolonged action of neodorm on the heart, recovery can be effected by suprarenin. Neodorm action shows itself to be dependent on temperature in accordance with the rule determined by H. H. Meyer, so that with increasing temperature and simultaneous increase in partition coefficient the narcotic activity increases. (33 salamander larvae) On (20) salamander larvae, after continued employment, "habituation" occurred; the cause of this has not yet been discovered.

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