+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Behavioral analysis of the effects and mechanisms of action of benzodiazepines

, : Behavioral analysis of the effects and mechanisms of action of benzodiazepines. Advances in Biochemical Psychopharmacology: 1-28

Conflict behavior is a powerful tool to reveal relevant pharmacologic correlates of the therapeutically desirable properties of benzodiazepine antianxiety compounds. The predictability of its clinical effectiveness in psychoneuroses is very high, and important quantitative and qualitative differences between compounds in this chemical class can be shown using such a behavioral technique. It is important to take these differences into account when studying biochemical correlates or mechanisms of action within the benzodiazepine class. Conflict behavior has been used to evaluate several biochemical hypotheses concerning the mechanism of action for the antianxiety properties of benzodiazepines. These studies found that inhibition of cyclic AMP phosphodiesterase did not seem to be a relevant factor. Similarly, experiments with AOAA did not provide evidence to support the involvement of GABA with benzodiazepines' antianxiety properties, nor did glycine receptor affinities correlate significantly with anticonflict effects. Thus, while it is reasonable at present to associate either GABA or glycine with the muscle-relaxant or anticonvulsant properties of benzodiazepines, no support was provided in the conflict procedure for their involvement in the anxiolytic effects. Partial support was provided for the proposal that serotonin is involved in the benzodiazepines' anxiolytic activity. This was determined in studies with the serotonin antagonists cinanserin and methysergide, which had anti-conflict activity, as well as in studies of monoamine turnover after initial chlordiazepoxide treatments to previously undrugged, conflict-trained rats.


PMID: 242196

Other references

Abidi, A.Z.; Kumar, A.; Tripathi, C.P.M., 1989: Impact of males on the numerical response of Diaeretiella rapae (M'Intosh) (Hym., Aphidiidae), a parasitoid of Lipaphis erysimi Kalt. (Hem., Aphididae). The effect of density of females and presence of males on the number of progeny produced by Diaeretiella rapae, a parasitoid of Lipaphis erysimi, was evaluated in the laboratory. The mean number of parasitoid progeny when females were kept singly...

Glaholm, J.; Brada, M.; Horwich, A., 1989: Hodgkin's disease of the epididymis and testis. Journal of the Royal Society of Medicine 82(9): 558-559

Saarinen, J., 1993: Focal attention and the perception of pattern structure in extrafoveal vision. Several studies have shown that visual attention enhances the encoding of the positional relationships between pattern elements, i.e., the perception of pattern structure. This theoretical note discusses the possibility that the inferiority of ext...

Gong, Y.S.; Chen, J.; Zhang, Q.Z.; Zhang, J.T., 2006: Effect of 17 beta -oestradiol and ginsenoside on osteoporosis in ovariectomised rats. To study the anti-osteoporosis effects and mechanism of action of oestradiol (E2) and ginsenoside (tR), we measured the bone mineral densities (BMD) of lumbar vertebra and tibia and analysed the tibia histological morphological data, as well obser...

Busche F.D.; Prinz Martin; Keil Klaus; Bunch T.E., 1971: Spinels and the petrogenesis of some Apollo 12 samples. Abstracts with Programs - Geological Society of America 3(7): 520-521

Rosenberg, H., 1977: Malignant hyperthermia syndrome. Anesthesia and Analgesia 56(3): 466-466

Cerasi, E.; Rudemo, M., 1975: Matematiska modeller i hormonforskning. Svensk Naturvetenskap, 111-119

Lin, Y.T.; Chiu, C.C.; Chen, Y.F.; Kao, E.L.; Yang, M.C., 1986: Surgical treatment of abdominal aortic aneurysm comparison between elective operation and emergency operation. Gaoxiong Yi Xue Ke Xue Za Zhi 2(7): 453-459

Gómez, Z., 1984: Hemangiomas. Treatment. Results of 15 treated cases. Acta Odontologica Venezolana 22(2): 105-120

Barbetti, P.; Chiappini, I., 1976: Identification of the furan group in the melanoidic pigments from a glucose glycine maillard reaction. A glucose-glycine model system was further investigated to provide new experimental data relating to the suggestion that 5-hydroxymethyl-2-furaldehyde may be 1 of the precursors to the melanoidic pigments. This study has relevance to food technolo...