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Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment

, : Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment. European Journal of Pharmacology 13(1): 131-133

Synthesis and release of 3H-dopamine (DA) were estimated by incubating slices of rat striatum with 3,5-3H-L-tyrosine and by measuring the 3H-amine accumulation in slices and incubating medium at the end of the incubation. Absolute 3H-DA synthesis was estimated by measuring the 3H-water quantities formed during the conversion of 3,5-3H-L-tyrosine to 3H-dopa. Amantadine pretreatment increased both 3H-DA synthesis and release. This drug effect on striatal dopaminergic terminals is discussed with respect to its utilization in human Parkinsonism.


PMID: 5496921

DOI: 10.1016/0014-2999(70)90194-9

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