+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Specific cellular unreactivity during cytomegalovirus infection in man

, : Specific cellular unreactivity during cytomegalovirus infection in man. Bollettino Dell'istituto Sieroterapico Milanese 57(4): 452-457

The specific cellular immune response against Cytomegalovirus (CMV) was studied by the Leucocyte Inhibitory Factor (LIF) production test in three groups of subjects: 7 healthy individuals with no CMV antibodies, 4 with antibodies to CMV but without evidence of active infection, and 2 children with clinical CMV infection. Our results show that LIF production in presence of CMV is high in normal seropositive subjects, while it is strongly deficient in patients with active infection, despite a good humoral response to the virus. In one child with congenital infection, a low number of E rosette forming cells was also revealed. We suggest that CMV infection can induce, at least during infancy, a state of specific cellular unresponsiveness to the virus. When the infection is congenital, a generalized depression of the cellular immune system may develop.


PMID: 216376

Other references

Coccioni, R.; Sideri, M.; Bancala, G.; Catanzariti, R.; Frontalini, F.; Jovane, L.; Montanari, A.; Savian, J., 2013: Integrated stratigraphy magneto-, bio- and chronostratigraphy and geochronology of the Palaeogene pelagic succession of the Umbria-Marche Basin central Italy. Extensive outcrops in the Umbria–Marche Basin of central Italy include some of the most complete successions of Palaeogene sediments known from the Tethyan Realm. Owing to the continuous deposition in a pelagic setting, a rather modest tecto...

Danil de Namor, A.F.; Al Nuaim, M.; Villanueva Salas, J.A.; Bryant, S.; Howlin, B., 2017: A calix[4]arene derivative and its selective interaction with drugs (clofibric acid, diclofenac and aspirin). The synthesis and characterisation of a partially substituted calix[4]arene, namely, 5,11,17,23-tetra-tert-butyl,25,27-bis[aminoethoxy] 26,28-dihydroxycalix[4]arene are reported. Its interaction with commonly used pharmaceuticals (clofibric acid,...

Davies, S.; Naik, P.C.; Lee, A.S., 1998: Lifetime risk of suicide in affective disorders. British Journal of Psychiatry 173: 185-185

Hogg, L.; Pack, G.T., 1956: Diagnostic accuracy of hepatic metastases at laparotomy. A.M.A. Archives of Surgery 72(2): 251-252

Ascaso, C.; Wierzchos, J.; Corral, J.Carmelo, 2003: New Applications of Light and Electron Microscopic Techniques for the Study of Microbiological Inclusions in Amber. Amber is a superb medium for the fossilization of delicate organisms. Besides light microscopy techniques for the study of insects in amber, scanning electron microscopy (SEM) in backscattered electron mode (SEM-BSE), low temperature SEM (LTSEM) a...

Farr, C.J.; Saiki, R.K.; Erlich, H.A.; McCormick, F.; Marshall, C.J., 1988: Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. In vitro DNA amplification followed by oligonucleotide dot blot analysis were used to study RAS gene mutations in acute myeloid leukemia (AML). Fifty-two presentation AML DNAs were screened for mutations in codons 12, 13, and 61 of NRAS and in cod...

Gerlach, C.V.; Das, S.R.; Volz, D.C.; Bisson, W.H.; Kolluri, S.K.; Tanguay, R.L., 2014: Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Firemaster 550 (FM550) is an additive flame retardant mixture used within polyurethane foam and is increasingly found in house dust and the environment due to leaching. Despite the widespread use of FM550, very few studies have investigated the po...

Kennedy, E.P.; Yeo, C.J., 2007: The case for routine use of adjuvant therapy in pancreatic cancer. Pancreatic cancer is a devastating disease with a poor prognosis for most patients. Surgical resection remains the cornerstone of treatment, providing the only realistic hope of long-term survival. Even with optimal surgical management, 5-year sur...

Takami, A.; Chuhjo, T.; Nakao, S., 2002: Relapse of chronic myeloid leukemia in lymphoid crisis after allogeneic bone marrow transplantation in chronic phase with a busulfan plus cyclophosphamide regimen. We report 3 cases of atypical relapse of chronic myeloid leukemia (CML) that presented with a sudden increase of lymphoid blasts, without preceding signs of chronic phase relapse, and viral infections after allogeneic bone marrow transplantation f...

Schöffling, K.; Beyer, J.; Ditschuneit, H.; Melani, F.; Böhle, E.; Walter, A.; Althoff, P.; Pfeiffer, E.F., 1965: On the modification of the biological serum insulin activities and of immunological insulin by hypophysectomy and growth hormone load. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 71: 355-359