geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of psychotropic drugs on dopamine uptake by synaptosomes and glial cells


, : Effect of psychotropic drugs on dopamine uptake by synaptosomes and glial cells. Bulletin of Experimental Biology and Medicine 87(3): 226-229

Uptake of dopamine-3H by synaptosomes and glial cells of the rabbit cerebral cortex and synaptosomes of the rat cerebral cortex was investigated. The value of Km for dopamine-3H uptake was found to be the same (0.0750.01 M) for both synaptosomes and glial cells. Rabbit cortical synaptosomes took up dopamine-3H twice as fast as glial cells (the rate of uptake was compared in terms of protein). Among the psychotropic drugs studied, the most active inhibitors of synaptosomal uptake were amphetamine and cocaine, but they were less active against glial uptake. Neuroleptics and antidepressants inhibited both types of uptake equally. The results are in agreement with the view that the mechanism of action of psychostimulants include a striatal dopaminergic component.

US$19.90

DOI: 10.1007/bf00801784


Other references

Prema, T.P.; Devarajaiah, C.; Reddamma, K.; Gopinath, P.S., 1987: Recreational activities for the mentally retarded: implications for nurse therapist. Nursing Journal of India 78(8): 207-208

Kim, J.Bin.; Park, D.Choon.; Cha, C.Il.; Yeo, S.Geun., 2007: Relationship between pediatric obesity and otitis media with effusion. To investigate the relationship between pediatric otitis media with effusion and obesity, as determined by body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) and serum triglyceride (TG) and total choleste...

Keränen, N.Susanna.; Kangas, M.; Immonen, M.; Similä, H.; Enwald, H.; Korpelainen, R.; Jämsä, T., 2017: Use of Information and Communication Technologies Among Older People With and Without Frailty: A Population-Based Survey. Use of information and communication technologies (ICT) among seniors is increasing; however, studies on the use of ICT by seniors at the highest risk of health impairment are lacking. Frail and prefrail seniors are a group that would likely benef...

Morimura, S.; Kida, K.; Nakagawa, M.; Sonoda, Y., 1994: Production of fungal protein by Aspergillus awamori var. kawachi grown in shochu distillery wastewater. The possibility of producing single cell protein (SCP) from shochu distillery wastewater by Aspergillus awamori var. kawachi has been examined. A yield of about 40 g/l of biomass, about 40% of which was protein, was obtained from a 24-h jar-fermen...

Ali S.A., 1982: Effect of carbohydrate starch level in purified diets on the growth of penaeus indicus. Four purified diets were formulated using casein, gelatin, starch, fish oil, groundnut oil, vitamins, minerals and cellulose. The carbohydrate in the diets was increased from 10-40% by varying the starch content to study the effect of dietary carb...

Husted, J.A.; Thavaneswaran, A.; Chandran, V.; Gladman, D.D., 2014: Incremental effects of comorbidity on quality of life in patients with psoriatic arthritis. To assess the added effect of comorbidity on quality of life (QOL) in psoriatic arthritis (PsA). Between 2006 and 2012, 631 patients were recruited from the University of Toronto PsA Clinic. Using the clinical database, we ascertained the frequenc...

Copeland, N.G.; Zelenetz, A.D.; Copper, G.M., 1980: Transformation by subgenomic fragments of Rous sarcoma virus DNA. Cell 19(4): 863-870

Duszczyk, M.; Ziembowicz, A.; Gadamski, R.; Wieronska, J.M.; Smialowska, M.; Lazarewicz, J.W., 2008: Changes in the NPY immunoreactivity in gerbil hippocampus after hypoxic and ischemic preconditioning. Preconditioning with sublethal ischemia or hypoxia may reduce the high susceptibility of CA1 pyramidal neurons to ischemic injury. In this study, we tested the hypothesis that enhanced level of neuropeptide Y (NPY) might play a role in the mechani...

Drummond-Goncalves, R., 1952: Liquid for the preservation of material intended for the museum. Full directions are given for the preservation of phytopathological material, comprising 6 to 24 hours' treatment with a fixative of 5 per cent. copper sulfate, two hours' washing, a fortnight's immersion in a solution of 5 to 6 per...

Fernández Valadés, R.; López de la Torre Casares, M.; Castilla, J.; Valladares Mendias, J.C.; Ruiz Montes, A.M.; Vílchez Joya, R.; Sánchez López-Tello, C., 1998: Gonadal, hormonal and spermatic function in patients treated for cryptorchidism. This paper studies the gonadal-hormonal and spermatic function of 48 adults (over 18 years old) who were treated in childhood for cryptorchidism by medical, surgical or both treatments. We measure plasmatic levels of FSH, LH, testosterone and prol...