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Epidemiology of hepatocellular carcinoma in Japan

, : Epidemiology of hepatocellular carcinoma in Japan. Hepatology Research 37 Suppl 2: S95-S100

Primary liver cancer, 95% of which is hepatocellular carcinoma (HCC), has ranked third in men and fifth in women as a cause of death from malignant neoplasm in Japan. Although the number of deaths and death rates from HCC increased until 2002 in Japan, annual deaths (34 089) and the death rate (27.0/100 000) from liver cancer decreased in 2003. Hepatitis C virus (HCV)-related HCC represents 75% of all HCC in Japan. The incidence of HCC without hepatitis B surface antigen (HBsAg) or anti-HCV accounted for 7-12% of HCC in Japan andhalf of non-B non-C-HCC was of unknown origin. Geographically, HCC is more frequent in western than eastern Japan, and the death rates from HCC in each prefecture correlate with the prevalence of anti-HCV, but not with HBsAg prevalence. Interferon therapy for chronic hepatitis C has reduced the risk factors for development of HCC, especially among patients with sustained response.


PMID: 17877503

DOI: 10.1111/j.1872-034X.2007.00169.x

Other references

Barnes, P.F.; Wizel, B., 2000: Type 1 cytokines and the pathogenesis of tuberculosis. There is debate regarding the correlation between in vitro susceptibility testing and clinical response to therapy for Bacteroides bacteremia. We conducted a prospective multicenter observational study of 128 patients with bacteroides bacteremia....

Armengol, R.; de Bernal, B.N.; Pérez de Fernández, B., 1994: Tuberculosis and AIDS in Venezuela. Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau 117(3): 262-269

Drüeke, T.; Witko-Sarsat, Véronique.; Massy, Z.; Descamps-Latscha, Béatrice.; Guerin, A.P.; Marchais, S.J.; Gausson, Vérie.; London, Gérard.M., 2002: Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease. Background: Increased common carotid artery intima-media thickness (CCA-IMT) is a marker of early atherosclerosis. Low-grade inflammation is associated with the pathogenesis of atherosclerosis. Low-grade inflammation and increased CCA-IMT are obse...

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Gorban', E.N.; Sykalo, N.V.; Pod"iachenko, E.V., 2012: Effect of Korargin on reactivity of isolation aorta of adult and old irradiated rats. Introduction to the diet of adult (7-8 months) and old (24-26 months) male rats for 30 days after a single R-irradiation at a dose of 5 Gy of preparation "Korargin" (whose active ingredients are L-arginine, contributing to the prevention...

Balter M.S.; Adams S.G., 1992: Inhaled steroids and laryngeal function effects of dosing schedule and inhalation aid devices. American Review of Respiratory Disease 145(4 PART 2): A744

Aleksandrov, I.A.; Iurov, I.B.; Mitkevich, S.P.; Gindilis, V.M., 1986: Cloned fragment of human alphoid DNA--a molecular marker of the pericentromeric region of chromosome 18. From the library of cloned fragments of human DNA we have isolated two recombinant plasmids containing alphoid DNA sequences pBRHS13, pBRHS65. Both cloned sequences hybridized in situ predominantly to pericentromeric regions of chromosome 18 and w...

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Arrese, C.; Archer, M.; Runham, P.; Dunlop, S.A.; Beazley, L.D., 2000: Visual system in a diurnal marsupial, the numbat (Myrmecobius fasciatus): Retinal organization, visual acuity and visual fields. The visual system of the numbat (Myrmecobius fasciatus), a highly endangered diurnal marsupial, has been investigated both anatomically and behaviorally. The ganglion cell layer, examined in cresyl-violet stained wholemounts, contained 832,800 gan...

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