geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The adaptable somatic repertoire


, : The adaptable somatic repertoire. Annales D'immunologie 135c(1): 137-142

Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, Vk167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutations may accumulate with time after joining of the V- and J-gene segments because IgG and IgA antibodies contain more amino acid substitutions than IgM antibodies. Many variant anti-phosphorylcholine antibodies have a higher affinity for antigen than their germ-line-encoded counterparts.

US$19.90

PMID: 6424549

DOI: 10.1016/S0769-2625(84)80023-9


Other references

Killick, LM.; Beverley-Burton, M., 1982: Observations on digeneans from lizards (Sauria) in Indonesia (Paradistomum geckonum, Mesocoelium sociale and Postorchigenes ovatus) with a revision of Paradistomum Kossack, 1910 (Dicrocoeliidae). An emended diagnosis for Paradistomum (= Paradistomoides) (Dicrocoeliidae) is given and P. geckonum is redescribed. P. geckonum occurred in the gallbladder or bile duct of Hemidactylus frenatus, Cosymbotus platyurus, Gehyra mutilata, Gekko gecko,...

Wang, S-Hong.; Nan, K-Jun.; Wang, Y-Chun., 2009: Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1. The function of T cells and B cells is to recognize specific "non-self" antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally...

Torres Rodriguez, J.M.; Sellart Altisent, M., 2006: Bilateral proximal cellulitis and onychomycosis in both big toes due to Fusarium solani. We report a case of proximal fold cellulitis in both big toes, associated with a bilateral proximal onychomycosis and an intertrigo of the fourth space due to Fusarium solani. The infection occurred in a 51-year-old immunocompetent man with diabet...

Huang, J.; Liu, X.; Tepelus, T.C.; Nazikyan, T.; Chopra, V.; Sadda, S.R.; Lee, O.L., 2017: Comparison of the Center and Flex-Center Methods of Corneal Endothelial Cell Analysis in the Presence of Guttae. To compare endothelial cell analysis by the center and flex-center methods in corneas with guttae of differing severity and to determine the minimum countable cell number for using only the flex-center method. Forty-seven eyes with corneal guttae...

Herman, R.; Kaplan, M.; LeMelle, S., 2002: Psychoeducational debriefings after the September 11 disaster. Psychiatric Services 53(4): 479-479

Ptushkina, M.; Fierro-Monti, I.; van den Heuvel, J.; Vasilescu, S.; Birkenhäger, R.; Mita, K.; McCarthy, J.E., 1996: Schizosaccharomyces pombe has a novel eukaryotic initiation factor 4F complex containing a cap-binding protein with the human eIF4E C-terminal motif KSGST. Genetic and biochemical analyses were performed on the cytoplasmic cap-binding complex (eukaryotic initiation factor (eIF) 4F) of Schizosaccharomyces pombe. Genomic and cDNA sequencing of the S. pombe gene (tif1) encoding the cap-binding component...

Czarniak,P.; Gorski,J., 2008: Proposal of new direct indicator of drill wear. Problem of different methods of drill wear estimation was presented. Besides new direct indicator of drill wear (which can be measured without microscope, only by means of standard digital camera) was tested.

Arbesman, C.E.; Walzer, M.; Swineford, O., 1955: Report of the Committee of the American Academy of Allergy on the acceptability of allergic donors in the American Red Cross Blood Program. Journal of Allergy 26(2): 181-186

Carpenter, K.J., 1994: Protein and energy A study of changing ideas in nutrition. The importance of protein (in particular certain amino acids) in human nutrition is universally accepted. This text traces the dramatic twists and turns in this acceptance in Western culture during the past three centuries. There are two main sect...

Turner, B.G.; Ramkrishna, D., 1988: Revised enzyme synthesis rate expression in cybernetic models of bacterial growth. A revised enzyme synthesis rate expression for cybernetic models of bacterial growth is presented. The rate expression, which is comprised of inducible and constitutive contributions, provides for a basal enzyme level that is necessary to predict...