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A comparison of the central actions of three tranquillizers and a neuroleptic

, : A comparison of the central actions of three tranquillizers and a neuroleptic. J Physiol [paris] 58(4): 409-425

The actions of a neuroleptic (triperidol) and 3 tranquillizers (chlor-diazepoxide, procalmadiol, and methylpentynol) were compared in a number of tests on mice. Two sets of tests enable to differentiate the neuroleptic from these tranquillizers. Motility (antagonism to D-amphetamine), evasion. On these the neuroleptic is very effective, and the tranquillizers either ineffective (procalmadiol, methylpentynol) or moderately active (chlordiazepoxide). Convulsive attacks (produced by electric shock, or acoustic epilepsy in mice sensitized by isoniazid or thiosemicarbazide), on which the neuroleptic has no effect, while the tranquillizers are very effective.


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