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A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases polymerases

, : A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases polymerases. Nature Structural Biology 5(11): 959-964, Nov

A novel class of DNA-binding domains has been established from at least sixteen recently identified DNA-binding proteins. The three-dimensional structure of one of these domains, Mrf-2, has been solved using NMR methods. This structure is significantly different from known DNA-binding domain structures. The mechanism of DNA recognition by this motif has been suggested based on conserved residues, surface electrostatic potentials and chemical shift changes. This new DNA-binding motif shares structural homology with T4 RNase H, E. coli endonuclease III and Bacillus subtilis DNA polymerase I. The structural homology suggests a mechanism for substrate recognition by these enzymes.


Other references

Takeuchi M.; Takasaki S.; Miyazaki H.; Kochibe N.; Kobata A., 1987: N linked sugar chains of urine human erythropoietin. Experimental Hematology (Charlottesville) 15(5): 585

Gizike A.; Keilis Borok V.I. (Keylis Borok V.I.; Kosobokov V.G.; Kuznetsov I.V., 1988: Diagnosis of periods of high probability of the strongest earthquakes of South America based on a set of seismological parameters. Computational Seismology: Earthquake Prediction and the Structure of the Earth 21: 21-26

Lima,; Martins, P.Custódio.; Junior, C.Alencar.Souza.Alves.; Castro, Jão.Antô; Silva, D.Augusto.Santos.; Petroski, E.Luiz., 2017: Are traditional body fat equations and anthropometry valid to estimate body fat in children and adolescents living with HIV?. The aim of this study was to assess the validity of traditional anthropometric equations and to develop predictive equations of total body and trunk fat for children and adolescents living with HIV based on anthropometric measurements. Forty-eight...

Schelling, P.; Fischer, H.; Hutchinson, J.; Ganten, D., 1975: Influence of angiotensin II and angiotensin II antagonist (P 113) in vitro on cell growth in 3T3 and virus transformed SV40 3T3 cells. Naunyn-Schmiedeberg's Archives of Pharmacology 287 Suppl: R51-R51

Naskidashvili, P.P., 1979: New forms of Triticum durum Desf. with branched ears. In the progeny of T. durum 'Coerulescens 19/28' X T. aestivum 'Akhaltsikhis Tsiteli Dolis Puri', plants with hybrid necrosis, red hybrid chlorosis and hybrid dwarfness segregated, together with various forms with branched ears.

Enright, T.Q., 1952: The revaluation of man; principles. Industrial Medicine & Surgery 21(2): 82-85

Cantor, D., 1987: State registration and the shortage of radiographers in the National Health Service 1948-1960. Society for the Social History of Medicine Bulletin 40: 69-73

Dobson, H.E.M.; Bergstrom, G.; Groth, I., 1990: Differences in fragrance chemistry between flower parts of rosa rugosa thunb. rosaceae. Fragrances (volatiles) from whole flowers, petals, sepals plus gynoecium, anthers, and pollen were collected from Rosa rugosa Thumb. by headspace adsorption methods and analyzed by gas chromatography/mass spectrometry. Each flower part showed a di...

Fauchald, P., 2010: Predator-prey reversal: a possible mechanism for ecosystem hysteresis in the North Sea?. Removal of large predatory fishes from marine ecosystems has resulted in persistent ecosystem shifts, with collapsed predator populations and super-abundant prey populations. One explanation for these shifts is reversals of predator-prey roles tha...

Kashiwamura S I.; Sakaguchi N.; Kimoto M.; Thalmann P.; Melchers F., 1988: The b lymphocyte lineage related gene mb 1 complementary dna structure and rna expression in different cell lineages. Journal of Cellular Biochemistry Supplement (12 PART B): 110