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Age-specific death rates of mice exposed to ionizing radiation and radiomimetic agents


, : Age-specific death rates of mice exposed to ionizing radiation and radiomimetic agents. R J C Harris, Editor Cellular Basis and Aetiology of Late Somatic Effects of Ionizing Radiation A Symposium 1962 p 285-297

The age-specific death rate increases irregularly with age, tending to rise exponentially with time beyond a certain age. Radiation and radiomimetic chemicals administered early in life increase the over-all age-specific death rate in a manner suggestive of ageing. When the age-specific death rates for individual diseases are analysed, the curves vary in shape and slope, and the effects of radiation appear quantitatively, if not qualitatively, variable. Age-specific death rates from radiogenic leukaemias (thymic lymphoma and myeloid leukaemia) appear unusual in that mortality from these diseases becomes maximal relatively early. . Analysis of the age-specific death rates for various other diseases, including non-neoplastic lesions, indicates that the life-shortening effects of radiation are not confined to induction of neoplasia or any other specific type of pathological change. Instead, they appear to be correlated with a general advancement in the age distribution of diseases otherwise associated with senescence. The results emphasize the complexity of the relation between the incidence of a disease and the radiation dose, owing to effects of radiation on intercurrent diseases affecting the survival of the population at risk.

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