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An experimental study on the mechanism of the secretion of milk I An experimental study on the physiological growth of the mammary gland II The relation between the anterior pituitary lobe and the mammary gland III The effect of the separate and combined action of follicular hormone, luteohormone and anterior pituitary hormone on the mammary gland IV The relation between the adrenal and the mammary glands


, : An experimental study on the mechanism of the secretion of milk I An experimental study on the physiological growth of the mammary gland II The relation between the anterior pituitary lobe and the mammary gland III The effect of the separate and combined action of follicular hormone, luteohormone and anterior pituitary hormone on the mammary gland IV The relation between the adrenal and the mammary glands. Jap Jour Obstet And Gynecol [Kinki Fujinkwa Gakkwai Zasshi] 22-23(4-6-1): 257-264, 376-386, 25-41

I. The small number of secretory ducts in the mammary glands in infant rabbits increased as maturity was reached. The ducts increased rapidly during pregnancy. The vessel walls usually consisted of a double layer of epithelium, but in the later stages of pregnancy and in the puerperium. secretory ducts of medium or small size with a single layer of epithelium began to appear; fat was evident within the cells. The amt. of interstitial tissue was in inverse proportion to the growth of the gland tissue. The "endoapparatus," "endochambers" and glandular lobes were usually absent in the mammary glands of the infant rabbits. A few "endoapparatus" but no "endochambers" were found in adult virgin rabbits. In the early stages of pregnancy the secretory ducts, "endoapparatus" and glandular lobes developed but not the "endochambers." In the later stages of pregnancy and the puerperium the "endochambers" showed quite rapid growth.[long dash]II. Infant $ rabbits and ovariectomized rabbits were given daily intrav. injs. of 20, 50, 100, 200 and 400 R.U. of gonadotrophin or praehormon (total 280-840 R.U.). Daily injn. of 20-200 R.U. of either hormone prep. resulted in a gradual increase in the growth of the mammary gland parallel to the dose injected; in the group which received 400 R.U. daily, however, the growth was about the same as in those which received 200 R.U. daily. The secretory development also increased gradually with the dosage up to 200 R.U.; it was extremely vigorous when 400 R.U. was administered daily. Gonadotrophin and praehormon acted upon the mammary gland chiefly, though not wholly, through the ovary; the action of both preps. was identical. The growth of the mammary gland did not parallel the secretion when acted upon by the ant. pituitary hormones.[long dash]III. Daily subcut. injns. of 100 I.U. of ovahormone benzoate (follicular hormone) for 21 days markedly accelerated the growth of the mammary glands in immature castrated rabbits; the growth was accelerated still further if 1 "K.E." oophormin (luteohormone) was also injected during the last 6 days. Daily inj. of 1000 I.U. of ovahormone benzoate or of water-soluble ovahormone for 6 or 7 days into puerperal guinea pigs beginning on the 1st day of the puerperium inhibited lactation; ovahormone benzoate had a greater inhibitory action than water-soluble ovahormone. This inhibitory action apparently originates in the midbrain. The subcut. inj. of 100 I.U. of ovahormone benzoate or of water-soluble ovahormone combined with the intraven. inj. of 200 R.U. of gonadotrophin daily for 21 days into immature, [female], non-castrated rabbits produced a greater acceleration of the growth of the mammary gland than the adm. of ovahormone benzoate or water-soluble ovahormone. If the rabbits which had received this treatment for 15 days followed by the adm. of water-soluble ovahormone, gonadotrophin and oophormin as above for 6 days were castrated 24 hrs. after the last inj., a marked acceleration of the secretory function appeared 72 hrs. later. Oophormin is particularly important for the growth of the "endoapparatus" of the mammary gland; it has practically no effect on lactation.[long dash]IV. Gradual atrophy of the mammary gland occurred in puerperal guinea pigs which were separated from their young 2 to 4 hrs. after delivery; secretion was still active, however, even on the 6th day of the puerperium. Daily subcut. injs. of 0.5 cc. of 0.1% adrenaline hydrochloride inhibited lactation. Daily subcut. injs. of 0.5 or 1.0 cc. interenin (cortical hormone) during the first 5 days of the puerperium inhibited lactation slightly.

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