+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Angiogenesis on encephalo-myo-synangiosis. The effect of basic fibroblast growth factor

, : Angiogenesis on encephalo-myo-synangiosis. The effect of basic fibroblast growth factor. Nihon Geka Hokan. Archiv für Japanische Chirurgie 62(2): 82-91

Moyamoya disease is characterized occlusion of Willis' artery ring and abnormal "moyamoya" vessels. By supplying sufficient blood flow to the distal area of the stenosis or occlusion, ischemic symptom could be improved and the risk of the hemorrhage are lessen. Encephalo-Myo-Synangiosis (EMS) can increase the blood supply from external carotid artery to the ischemic area just put the temporal muscle on the brain surface. A kind of growth factor are thought to be exist around the brain of the Moyamoya disease patient. Basic fibroblast growth factor (bFGF) contribute angiogenesis in vitro and in vivo. This effect is considered to grow tumors and many experiments are done to use it for therapy by blocking this effect. Few trials are done to utilize the angiogenetic effect for therapy. We studied the effect of the bFGF on angiogenesis after EMS by using rats. We operated EMS on 10 male SDrats. 0.1 microgram of the bFGF was poured on 5 rats between the brain and muscle. On the other 5 rats just saline was poured. One week after rats were sacrificed, new vessels were observed with light microscope and scanning electron microscope. Molding models were also observed. bFGF group grew larger new vessels between the brain and muscle than non bFGF group. On the surface of brain, bFGF had more larger vessels (diameter is over 6 um) and non bFGF group had more small vessels (less than 6 um). Total area of vessel of bFGF group was twice as large as that of non bFGF group. On molding models many closed end of vessels were seen and they were thought to be the growing vessels. In molding models, bFGF group also has larger vessels than non bFGF group. We could prove that bFGF promotes angiogenesis on EMS of the rats, and we also expect that bFGF help the supplying blood flow of the Moyamoya patient.


PMID: 7694557

Other references

Orabona, P.; D'Antonio, A.;, I.; Boscaino, A., 1994: Unusual clinical manifestation of metastatic pulmonary carcinoma. A case report and review of the literature. We report a case of ileal metastasis from a clinically evident bronchial carcinoma with an unusual symptomatology due to intestinal obstruction. Only 25 cases of ileal metastasis have been previously reported in the literature in which the diagnos...

Pérez Huertas, P.; Cueto Sola, M.; Escobar Cava, P.; Borrell García, C.; Albert Marí, Aón.; López Briz, E.; Poveda Andrés, Jé.Luis., 2015: Applying dose banding to the production of antineoplastic drugs: a narrative review of the literature. La dosificación de los fármacos antineoplásicos se ha basado históricamente en la prescripción y elaboración individualizada según la superficie corporal o peso del paciente. La falta de recursos y el aumento de la carga asistencial en las...

Wurch, T.; Matsumoto, A.; Pauwels, P.J., 2001: Agonist-independent and -dependent oligomerization of dopamine D2 receptors by fusion to fluorescent proteins. Oligomerization of the short (D(2S)) and long (D(2L)) isoforms of the dopamine D(2) receptor was explored in transfected Cos-7 cells by their C-terminal fusion to either an enhanced cyan or enhanced yellow fluorescent protein (ECFP or EYFP) and th...

Wolfson, E., 1966: Thoughts on the present and future status of the private practice of dentistry. Oral Hygiene 56(6): 54-6 Passim

Song, R.B.; Vite, C.H.; Bradley, C.W.; Cross, J.R., 2015: Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. Intracranial neoplasia of dogs is frequently encountered in veterinary medicine, but large-scale studies on prevalence are lacking.To determine the prevalence of intracranial neoplasia in a large population of dogs examined postmortem and the rela...

Shimpo, K.; Beppu, H.; Chihara, T.; Kaneko, T.; Shinzato, M.; Sonoda, S., 2007: Effects of aloe arborescens ingestion on azoxymethane-induced intestinal carcinogenesis and hematological and biochemical parameters of male F344 rats. We examined the modifying effect of freeze-dried whole-leaf Aloe arborescens Miller var. natalensis Berger (Kidachi aloe in Japan; designated as 'ALOE') on azoxymethane (AOM)-induced intestinal carcinogenesis in rats. Male F344 rats (4 w...

Kozlova P.S.; Gurvich M.Y., 1979: The behavior of uranium in postmagmatic alteration of potassic alkali rocks. Geochemistry International 16(4): 109-117

Elizabeth, K.E., 2017: Remodel ICDS Centers as Early Child Care and Education Centers. Indian Pediatrics 54(7): 602-603

Varghese, M.; Qadeer, I.; Mohan, D., 1997: Paralytic poliomyelitis in a rural area of north India. Background: Paralysis due to poliomyelitis is common in rural areas. The extent of paralysis, type and piece of treatment and effect of local treatment on children with poliomyelitis was assessed in a house-to-house survey conducted between 1990 a...

Lee, C.Hyun.; Ahn, J.Hyeon.; Won, M-Ho., 2016: New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia. 5-Hydroxytryptamine (5-HT, serotonin) plays protective or detrimental roles in the development of ischemic damage. In the present study, we investigated the time-course changes in 5-HT1A receptor protein expression in the gerbil hippocampal CA1 re...