+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats

, : Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats. Food and Chemical Toxicology 46(10): 3262-3267

To find whether pretreatment of Ulva lactuca polysaccharide (ULP) extract could be effective against D-Galactosamine (500 mg/kg body weight, i.p.) induced anomaly in rat. Serum total cholesterol (TC), triglycerides (TG), free fatty acid (FFA), phospholipids (PL), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), tissue lipoperoxides (LPO), hepatic protein thiols, non-enzymatic anti-oxidants glutathione (GSH) and vitamins (E and C) were examined using spectrophotometer. The ultra structural changes of liver during D-Galactosamine and protection offered by ULP were examined by electron microscopy. Seaweed histology and chemical composition of polysaccharides in seaweed were examined. Alcian blue staining showed the presence of sulphated polysaccharide with total sugar (65.4%), sulphate (17.4%), and uronic acid (17.2%) content. D-Galactosamine intoxicated rats showed significant (p<0.01) liver damage with acute aberration in serum lipid profile, hepatic protein thiols and tissue non-enzymatic anti-oxidants. Assorted deposits of lipid droplets and abnormal appearance of mitochondria was observed in electron microscopy study. Rats pretreated with ULP (30 mg/kg body weight/day/for 21 days) showed a significant inhibition (p<0.05) against abnormality induced by D-Galactosamine. U. lactuca exhibit anti-peroxidative and anti-hyperlipidemic property.


PMID: 18706469

DOI: 10.1016/j.fct.2008.07.016

Other references

Anas, P.; Neely, W.A.; Hardy, J.D., 1968: Relation of oxygen consumption to hemodynamic changes in experimental endotoxin shock. The course of endotoxin shock was observed in 10 dogs with measurements being made of cardiac output, central blood volume, mean arterial and pulse pressures, hematocrit, O2 consumption, arterial and venous O2 consumption, arterial and venous O2 s...

Yende,S.R.; Harle,U.N.; Rajgure,D.T.; Tuse,T.A.; Vyawahare,N.S., 2008: Pharmacological profile of Acorus calamus an overview. <i>Acorus calamus</i> (Acoraceae), also known as Calamus or Sweet Flag is commonly used herbal medicine in Ayurvedic system. It is a semi aquatic herb growing in shallow water or in a very moist loamy soil. Roots and rhizomes of <i&...

Kisslinger; Li, 1995: Gauge invariant electromagnetic two-point function for heavy-light quark systems. Physical Review Letters 74(12): 2168-2171

Blumenthal, K.M.; Smith, E.L., 1975: Alternative substrates for glutamate dehydrogenases. Biochemical and Biophysical Research Communications 62(1): 78-84

Zacco, M.; Colonna, L.; Manganelli, G., 1957: Study of clinical aspects and water, sodium and potassium excretion during treatment with ACTH, cortisone and related compounds. Folia Endocrinologica; Mensile di Incretologia E Incretoterapia 10(1): 23-39

Love, R.P.; Xu, H.; Chelico, L., 2012: Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A. APOBEC3A belongs to a family of single-stranded DNA (ssDNA) DNA cytosine deaminases that are known for restriction of HIV through deamination-induced mutational inactivation, e.g. APOBEC3G, or initiation of somatic hypermutation and class switch r...

Burton, C.H.; Richardson, C.W.; Jobes, R.A., 1979: Determining the costs and returns of producing milk in the southwest. Quarterly budgets of costs and returns have been prepared since 1973 in 5 southwestern states of the USA, and since 1976 also in 7 northern and midwestern states. The budgets are used in milk pricing and in planning dairy farm operations.

Lewis, M., 2002: PRELP, collagen, and a theory of Hutchinson-Gilford progeria. Proline/arginine-rich end leucine-rich repeat protein (PRELP) a small leucine-rich proteoglycan (SLRP), binds type I collagen to basement membranes and type II collagen to cartilage. Evidence for lack of binding of collagen in basement membranes a...

Yamada Naotoshi; Nakai Yutaka; Danhara Toru, 1987: Fission-track ages of the Sennan rhyolites and the Suyama pyroclastic rock from the southern margin of the Ryoke Belt, Southwest Japan. Chishitsugaku Zasshi = Journal of the Geological Society of Japan: , Pages 287-299. 1987.

Anonymous, 1956: Artificial kidney of Necker Hospital. Techniques Hospitalieres, Medico-Sociales et Sanitaires 12(134): 29-30