+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antifibrin scintigraphy in the diagnostic evaluation of acute deep venous thrombosis

, : Antifibrin scintigraphy in the diagnostic evaluation of acute deep venous thrombosis. Seminars in Nuclear Medicine 21(4): 313-324

Antifibrin scintigraphy is a new and innovative approach to the diagnosis of acute deep venous thrombosis (DVT). Many antifibrin monoclonal antibodies (Mo-Abs) have been described, but only two, 59D8 and T2G1s, have undergone broad preclinical or clinical investigation. Both of these MoAbs recognize an epitope on the amino terminal end of fibrin. The epitope for 59D8 and T2G1s is available for binding only on newly formed, acute thrombi. Preclinical studies have confirmed the specificity of these MoAbs for acute DVT, and have demonstrated their ability to image experimentally induced DVT. Preliminary clinical studies in patients with signs or symptoms of DVT have evaluated indium-111 59D8 Fab and technetium-99m T2G1s Fab'. Fragments of the intact MoAbs are employed to promote faster blood clearance and to reduce immunogenicity. The initial clinical studies indicate that antifibrin scintigraphy has a diagnostic accuracy approaching 90%. Antifibrin scintigraphy has the potential for overcoming many of the deficiencies of both invasive (contrast venography) and noninvasive (Doppler/ultrasound, impedance plethysmography) methods for detecting DVT. With a single procedure, it provides an accurate and rapid evaluation of both lower extremities, both above and below the knee. Because of its unique specificity for acute DVT, it should have excellent potential for use in patients with suspected acute, recurrent DVT, a condition difficult to diagnose by all currently employed tests for DVT.


PMID: 1754893

DOI: 10.1016/s0001-2998(05)80134-5

Other references

Moore, K.C.; Davis, G.R., 1985: Physical and catalytic properties of amylase from the alimentary canal of the migratory grasshopper, Melanoplus sanguinipes (Fab.). Archives Internationales de Physiologie et de Biochimie 93(2): 171-174

Wunderlich, J., 1994: The study of Mediterranean species of the genus Enoplognatha Pavesi 1880, with a new description Arachnida Araneae Theridiidae Zur Kenntnis mediterraner Arten der Gattung Enoplognatha Pavesi 1880, mit einer Neubeschreibung Arachnida Araneae Theridiidae. Beitraege zur Araneologie, 4: 703-713

Yen, J.T., 2014: Beamforming of sound from two-dimensional arrays using spatial matched filters. Fully-sampled two-dimensional (2D) arrays can have two-way focusing of the ultrasound beam in both lateral directions leading to high quality, real-time three-dimensional (3D) imaging. However, fully-sampled 2D arrays with very large element count...

Dotson, J.L.; Crandall, W.V.; Zhang, P.; Forrest, C.B.; Bailey, L.Charles.; Colletti, R.B.; Kappelman, M.D., 2015: Feasibility and validity of the pediatric ulcerative colitis activity index in routine clinical practice. The Pediatric Ulcerative Colitis Activity Index (PUCAI) is a noninvasive disease activity index developed as a clinical trial endpoint. More recently, practice guidelines have recommended the use of PUCAI in routine clinical care. We therefore sou...

Lörtscher, E.; Ciszek, J.W.; Tour, J.; Riel, H., 2006: Reversible and controllable switching of a single-molecule junction. Small 2(8-9): 973-977

Smith, B.; Coughlin, M., 2009: Reconstruction of a chronic extensor hallucis longus tendon laceration with a gracilis tendon autograft. Extensor hallucis longus tendon injuries are uncommon, representing < 2% of tendon injuries. Lacerations are more common than spontaneous ruptures, and if neglected are often difficult to primarily repair because of tendon retraction and scarri...

Gao, X.; Liu, X.; Lin, Z.; Liu, S.; Su, X., 2013: CuInS2 quantum dots as a near-infrared fluorescent probe for detecting thrombin in human serum. This paper describes a novel, simple method for the highly sensitive and selective detection of thrombin using fibrinogen (Fib) and CuInS(2) quantum dots (QDs) as biosensing probes. Water-soluble near-infrared CuInS(2) QDs capped by mercaptopropio...

Richter, Otto., 1908: Beobachtungen aus dem Liebesleben der Spinner. Internationale Entomologische Zeitschrift Guben, 2 219-220

Provost Alden; Voss Clifford, 1996: The evolution of lava fabrics; numerical simulations of sequential flow emplacement. Contributions of the Economic Geology Research Unit 56: 58-59

Gupta, I.; Mali, K.L., 1988: Alkaline and acid phosphatases in the tissues and serum of uninfected and infected host cattle egret (Bubulcus ibis coromandus) infected with digenetic trematode Pegosomum egretti. Alkaline and acid phosphatase activities were measured in the tissues and serum of B. ibis coromandus infected or uninfected with P. egretti. The optimum activities for alkaline and acid phosphatases were obtained at pH 10.0 and 5.0, respectively,...