+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antileishmanial action of organometallic complexes of Pt and Rh

, : Antileishmanial action of organometallic complexes of Pt and Rh. Memorias do Instituto Oswaldo Cruz 91(5): 627-635

The three organometallic complexes ((Cis-Pt-II (DDH) (2,5-Dihidroxibenzensulfonic)-2, Rh-I (CO)-2 Cl(2-Aminobenzothiazole) and Rh-I (CO)-2 Cl(5-Cl-2-Methilbenzothiazole)) used in this study had been previously found to have a high in vitro activity against promastigote and amastigote like forms of Leishmania donovani. Here, the cytotoxic effect of these new organometallic complexes on the J-774 macrophages were studied. Only the Rh-I (CO)-2 Cl(2-Aminobenzothiazole) complex induced substantial toxicity in the cells. Also, we assayed the effect of this complex on the parasite's biosynthesis of macromolecules. The Rh-I (CO)-2 Cl(5-Cl-2-Alethylbenzothiazole) complex inhibited DNA, RNA, and protein synthesis. On the other hand, the two other compounds tested did not inhibit the incorporation of radioactive precursors. Finally important ultrastructural alterations in the parasites treated with the two non-cytotoxic complexes were observed.


PMID: 9137749

Other references

Krott, P., 1959: Der Vielfrass (Gulo gulo L. 1758). Zur Kenntnis seiner Naturgeschichte und seiner Bedeutung fur den Menschen. Monographien der Wildsaugetiere, 13 i-vii 1-159

Medina, M.-Fatima; Winik, B., C.; Crespo, C., A.; Ramos, I.; Fernandez, S., N., 2000: Subcellular localization of Ca-ATPase and calcium in Bufo arenarum oviducts. The localization of calcium and Ca-ATPase activity in Bufo arenarum oviducts was investigated by ultrahistochemical techniques during the sexual cycle. In the preovulatory period prominent calcium deposits were detected in the secretory granules o...

D.B.lbao, F.; Guarin Corredor, E.; Nef, P.; Deiber, M.P.; Dubois Dauphin, M., 1998: Rapid induction of cpp32 mRNA synthesis in axotomized facial motoneurons of wild type and BCL-2 transgenic adult mice. Society for Neuroscience Abstracts 24(1-2): 1790

Nelson, W.A.; Adams, N.M., 1993: Nesophila hoggardii gen. et sp. nov. (Rhizophyllidaceae, Rhodophyta) from offshore islands of northern New Zealand. A new genus and species of marine Rhodophyceae, Nesophila hoggardii, is described and assigned to the Rhizophyllidaceae. Thalli consist of flattened, dichotomously branched axes, with acute apices and a prominent axial row of very large cells surr...

Kertesz, Coloman., 1908: Catalogue Dipterorum hucusque descriptorum Vol 3. Unknown

Maiti, R.K.; Vidyasagar, P.; Shahapur, S.C.; Seiler, G.J., 2005: Genotypic variability in seed dormancy in sunflower (Helianthus annuus L.) genotypes and the effects of periods of priming in breaking dormancy and improving seedling vigour. The variability in the dormancy of 59 sunflower genotypes was determined under laboratory conditions. In a related experiment, the effects of hydro-priming for 15 and 20 h on the breaking of dormancy of sunflower seeds were determined. The genotyp...

Stieger, R.; Thalhammer, C., 2015: 71-year-old man after partial resection of the right kidney. Deutsche Medizinische Wochenschrift 140(1): 17-17

Anonymous, 2005: Autumn Scientific Meeting of the Association of Cardiothoracic Anaesthetists, Windermere, United Kingdom, 3 November 2000. Abstracts. Critical Care 5 Suppl A: 1-7

Hoare, W.W., 1935: Conjunctivoplasty. British Journal of Ophthalmology 19(4): 235-236

Glass, C.K., 2001: Antiatherogenic effects of thiazolidinediones?. Arteriosclerosis, Thrombosis, and Vascular Biology 21(3): 295-296