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Biochemical and biological aspects of the plasminogen activation system


, : Biochemical and biological aspects of the plasminogen activation system. Clinical Biochemistry 23(3): 197-211

Plasminogen activators (PAs) are specific proteolytic enzymes which convert the inactive proenzyme plasminogen to plasmin. The plasmin formed is a potent and nonspecific protease which cleaves blood fibrin clots and several other extracellular proteins. In addition to their primary role in the initiation of fibrinolysis, PAs are implicated in a variety of basic biological processes, such as, degradation of the extracellular matrix, tumor invasiveness, tissue remodelling, and cellular differentiation. This review describes recent observations on the biochemical and biophysical characteristics of the different components of the plasminogen activation system. This complex system includes: the proenzymes of tissue type PA (tPA) and urokinase type PA (uPA); the active enzymes tPA, uPA and plasmin; the substrate plasminogen; several natural inhibitors of PA and plasmin activity; and the cellular receptors that bind the proenzymes, enzymes, and inhibitor-enzyme complexes. Through the coordinated interactions of these components, the location, timing, and extent of potent proteolytic activity is controlled. Recent findings on the structure, properties, biological functions, and regulation of the different components of the plasminogen activation cascade are reviewed. Current methods for assay of the amount and activity of the enzymes, inhibitors, and receptors are described. Observations implying specific functions of the system in health and disease, and its potential utilization for diagnosis are examined. Specifically, the potential application of PAs as laboratory markers of neoplasia, as diagnostic tools in diseases of the blood clotting system, their use for monitoring of thrombolytic therapy, and their possible relevance in certain disease states are described.

US$19.90

PMID: 2197030

DOI: 10.1016/0009-9120(90)90601-p


Other references

Sorlin, P.; Vandamme, P.; Nortier, J.; Hoste, B.; Rossi, C.; Pavlof, S.; Struelens, M.J., 1999: Recurrent "Flexispira rappini" bacteremia in an adult patient undergoing hemodialysis: case report. A blood culture from a 65-year-old febrile man undergoing hemodialysis revealed, 5 days after inoculation, an unusual gram-negative fusiform rod with darting motility. During another episode of fever 21 days later, this Campylobacter-like organism...

Hinton, A.; Gatti, D.L.; Ackerman, S.H., 2004: The molecular chaperone, Atp12p, from Homo sapiens. In vitro studies with purified wild type and mutant (E240K) proteins. Work in Saccharomyces cerevisiae has shown that Atp12p binds to unassembled a subunits of F1 and in so doing prevents the alpha subunit from associating with itself in non-productive complexes during assembly of the F1 moiety of the mitochondrial...

Werner, H.; Heizmann, W.R.; Freuer, G.; Mitinis, N.; Heilmann, F., 1989: Efficacy of clavulanate-potentiated antibiotics against Bacteroides species and artificially associated cultures of aerobes and anaerobes. Clavulanic acid is known to potentiate the activity of amoxycillin and ticarcillin against beta-lactamase-producing Bacteroides species. In order to assess the usefulness of the clavulanate antibiotics in mixed infections with aerobes and anaerobe...

Mikata, I., 1963: Slight Fever. Naika. Internal Medicine 12: 860-864

Kjellström, T.; Norrving, B.; Shatchkute, A., 2006: Helsingborg Declaration 2006 on European stroke strategies. The Second Consensus Conference on Stroke Management took place from 22 to 24 March 2006 in Helsingborg, Sweden. The meeting was arranged by the International Stroke Society, endorsed by the European Stroke Council and International Stroke Society...

Hart, B.P.; Mcconnell, W.T.; Pickett, A.N., 1944: Vitamin and endocrine therapy in nausea and vomiting of pregnancy. 43 patients with vomiting of early pregnancy received pyridoxine hydrochloride in doses of 50-100 mg. daily and intravenously. Of these, 25 were primigravidas and about 75% was relieved completely; 18 were multigravidas, only 33% was ameliorated....

Czyzyk, A., 1961: On the behavior of amino-nitrogen and of free amino acids in the plasma in diabetes mellitus. Zeitschrift für die Gesamte Innere Medizin und Ihre Grenzgebiete 16: 196-203

Liao, C.; Chien, I.; Chung, M.; Chiu, J.; Han, Y., 1979: A study of sweetpotato virus d. Chung hua nung yeh yen chiu = Journal of agricultural research of China 28(3): 127-138

Yang, C.; Sgroi, D.; Gaudet, J.; Schmidt, E.V., 2002: Analysis of second hits in mammary carcinogenesis using differential gene expression in transgenic mice Use of laser capture microdissection and microarray. Proceedings of the American Association for Cancer Research Annual Meeting 43: 465, March

Pobloth, A.; Macha, H.N., 1995: The level of risk in endobronchial laser resection under general anaesthesia. European Respiratory Journal 8(SUPPL 19): 497S