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Biopersistences of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures


, : Biopersistences of man-made vitreous fibers and crocidolite fibers in rat lungs following short-term exposures. Environmental Health Perspectives 102 Suppl 5: 139-143

Biopersistence of commercial man-made vitreous fibers (MMVF) and crocidolite were studied in Fischer 344 rats. MMVF used were size-selected to be rat-respirable, and rats were exposed nose-only 6 h/day for 5 days to gravimetric concentrations (30 mg/m3) of two fiber glass compositions--a rockwool, and a slagwool--or to 10 mg/m3 of long-fibered crocidolite, or to filtered air. Animals were sacrificed at 1 hr, 1, 5, 31, 90, 180, 270, 365, and 545 days after exposure stopped. Fibers were recovered from digested lung tissue to determine changes in concentrations (fibers/mg dry lung) and fiber retentions (expressed as percent of day 1 retention [PR]) for selected dimension categories. One-day average concentrations of lung-retained MMVF and crocidolite fibers, of diameter > or = 0.5 micron or > 20 microns in length, were nearly equal, permitting direct comparisons between MMVF and crocidolite. At 270 days average PR for MMVF > or = 0.5 micron in diameter were from 3 to 6 +/- 2% and 27 +/- 9% for crocidolite. For fibers > 20 microns, PR were 1 to 4 +/- 4% for MMVF and 37 +/- 20% for crocidolite. At 545 days, MMVF > 20 microns in length were at background level while concentration of crocidolite fibers > 20 microns in length remained at 2000 +/- 400 f/mg DL (dry lung), or 38 +/- 9% of day-1 retention. These results suggest strongly that MMVF dissolved or fractured in vivo whereas crocidolite fibers did not change.

US$29.90

PMID: 7882918


Other references

Barris, M.C.; Dawson, W.W.; Trick, L.R., 1981: LASCER Bode plots for normal, amblyopic, and stereoanomalous observers. Indices of laterality, interocular response latency difference, and binocular summation derived from Bode plots (amplitude-versus-temporal frequency and phase lag-versus-temporal frequency) of cortical responses evoked by laser speckle (LASCER) ar...

Mallick, A.; Vidya, K.C.; Waran, A.; Rout, S.Kumar., 2017: Measurement of Lingual Cortical Plate Thickness and Lingual Position of Lower Third Molar Roots Using Cone Beam Computed Tomography. The objective of the study was to determine the potential risk of tooth/root displacement into the soft tissue during the third molar surgery. While performing third molar surgeries, one of the many complications is displacement of the tooth into...

Mintz, G.S.; Pichard, A.D.; Kent, K.M.; Satler, L.F.; Popma, J.J.; Wong, S.C.iu; Painter, J.A.; Deforty, D.; Leon, M.B., 1995: Endovascular stents reduce restenosis by eliminating geometric arterial remodeling A serial intravascular ultrasound study. Journal of the American College of Cardiology 0(SPEC ISSUE): 36A

Vikram, C.S.; Vedam, K., 1983: Selective counting path of Young's fringes in speckle photography for eliminating diffraction halo effects. Applied Optics 22(15): 2242-2243

Badowski, A.; Stanowski, E., 1972: Case of intramural gastric neurilemmoma complicated by hemorrhage. Wiadomosci Lekarskie 25(17): 1559-1562

Mannon, R.B.; Hoffmann, S.C.; Kampen, R.L.; Cheng, O.C.; Kleiner, D.E.; Ryschkewitsch, C.; Curfman, B.; Major, E.; Hale, D.A.; Kirk, A.D., 2005: Molecular evaluation of BK polyomavirus nephropathy. Understanding at a molecular level, the immunologic response of polyomavirus nephropathy (PVN), a critical cause of kidney graft loss, could lead to new targets for treatment and diagnosis. We undertook a transcriptional evaluation of kidney allog...

Farina, A.; Vesce, F.; Garutti, P.; Jorizzo, G.; Bianciotto, A., 1999: Evaluation of intrauterine growth pattern of twins by linear discriminant analysis of the values of biparietal diameter, femur length and abdominal circumference1. In a cross-sectional study, the intrauterine growth pattern of 32 twins was compared to that of 205 singletons by analysis of the coefficients of the equations of biparietal diameter (BPD), femur length (FL) and abdominal circumference (AC). Lower...

Wykes T., 1981: Inference and childrens comprehension of pronouns. Two experiments are reported that investigate the ability of 5 yr olds to determine the reference of anaphoric pronouns. Children have problems coping with more than 1 pronoun in a sentence and if they have to draw an inference to define the refer...

Fujita, M.; Ito, H.; Hayakawa, K., 1974: Primary lymphosarcoma of the lung, report of an autopsy case. Hokkaido Journal of Medical Science 49(3): 257-261

Luria, S.M.; Kinney, J.A.n S.; Weissman, S., 1965: Estimation of size and distance underwater. Estimates of size and distance of unknown objects in air and in water were compared. Estimates were made both by trained SCUBA divers and by randomly selected subjects. A 4-in. square target was positioned at 5 and 12 ft. from the subject for the...