+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature

, : Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature. Medicine 74(3): 144-151

We report 4 patients who developed a severe systemic hypersensitivity reaction when taking carbamazepine, To prove hypersensitivity to carbamazepine, we performed patch tests and in vitro lymphocyte transformation tests. Patch tests were uniformly and strongly positive in patients and negative in controls. Lymphocyte transformation tests were positive in 3 of 4 patients. We reviewed the literature on reports of carbamazepine-induced pseudolymphoma and other severe systemic hypersensitivity reactions. Considering the many common clinical, biochemical, and pathologic characteristics, we propose to group these reactions under the term "carbamazepine hypersensitivity syndrome." The syndrome is characterized by the development of fever, rash, and lymphadenopathy between 1 week and 3 months after the introduction of carbamazepine. A variety of other target organs may be involved, including the liver, kidneys, and lungs. The carbamazepine hypersensitivity syndrome is a clinical diagnosis. Patch tests and lymphocyte transformation tests are valuable tools to confirm the diagnosis, but are reliable only after all signs subside. Similar syndromes have been described with the other aromatic anticonvulsants (phenytoin, the other hydantoins, and phenobarbital), and there is evidence of a cross-reaction between carbamazepine and phenytoin. It is unknown whether the carbamazepine hypersensitivity syndrome should be considered a premalignant state, with an increased risk for the development of malignant lymphoma.


PMID: 7760721

DOI: 10.1097/00005792-199505000-00004

Other references

Farres, M.T.resa; Gattegno, B.; Ronco, P.; Flahault, A.; Paula Souza, R.; Bigot, J.M.chel, 2000: Nonnephrotoxic, dynamic, contrast enhanced magnetic resonance urography: Use in nephrology and urology. Purpose: We assessed the value of breath-hold, gadolinium (Gd) enhanced magnetic resonance urography for diagnosing urinary tract disease. Materials and Methods: Dynamic magnetic resonance urography was performed in 38 consecutive patients present...

Campbell P.E.; Crumbaugh C.M.; Rhodus D.M.; Knouse S.B., 1971: Magnitude of partial reward and amount of training in the rat a hypothesis of sequential effects. Journal of Comparative & Physiological Psychology 75(1): 120-128

Del Rio J.; Lasheras B.; Berjon A.; Romero G.; Del Castillo J.C.; Roca J.; Monge A., 1992: Novel 5 ht 3 receptor antagonists quinoxaline derivatives with antiemetic activity in ferrets. Bianchi, A L , Et Al (Ed ) Colloque Inserm (Institut National De La Sante Et De La Recherche Medicale), Vol 223 Mecanismes Et Controle Du Vomissement; (Inserm (National Institute Of Health And Medical Research) Colloquium, Vol 223 Mechanisms And Control Of Emesis); International Meeting on New Vistas on Mechanisms And Control Of Emesis, Marseille, France, September 4-7, Xxii+371p Editions Inserm: Paris, France; John Libbey Eurotext: London, England, Uk Illus Paper 245-246

Sirtori, C.M., 1965: Findings on obstetric prophylaxis in the Milan population. Rivista D'ostetricia E Ginecologia Pratica 47(4): 387-414

Gargasas, L.V., 1964: Certain Social-Economic Factors And Rheumatism. Sovetskoe Zdravookhranenie 23: 52-53

Bogomil'skiĭ, M.R., 1965: Role of allergy in chronic highmoritis. Zhurnal Ushnykh, Nosovykh i Gorlovykh Boleznei 25(3): 21-24

Cornwell, H.J.; Paterson, S.D.; McCandlish, I.A.; Thompson, H.; Wright, N.G., 1983: Immunity to canine adenovirus respiratory disease: effect of vaccination with an inactivated vaccine. Nine puppies without maternal antibody to canine adenovirus (CAV) were divided into two groups. The first consisted of six puppies, each of which was given two doses of a commercial inactivated CAV-1 vaccine, 14 days apart. Eight days after admini...

Frances, V.; Pandrau Garcia, D.; Guret, C., 1994: A surrogate 15 kDa JCk protein is expressed in combination with m heavy chain by human B cell precursors. The EMBO Journal 13: 37-43

Minchin, F.; Witty, J.; Sheehy, J., 1984: Errors in the acetylene reduction assay: determined using a flow-through system. Advances in agricultural biotechnology(4): 40

Burns S.F., 2002: Reactivation of ancient landslides in Pacific Northwest Oregon from 1996 to 2002. Pages 35 2002