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Chemical synthesis of peptide libraries

, : Chemical synthesis of peptide libraries. Bioorganic & Medicinal Chemistry Letters 3(3): 413-418

The efficiency of the “portioning-mixing” method is demonstrated by the synthesis of more than one million hexapeptides in 5 days. An example is described to illustrate the possibility of completion of partial peptide libraries. Our method is also shown to be suitable to carry out binary peptide synthesis. In addition, a new screening method is outlined based on specific interaction of peptides with living cells.


DOI: 10.1016/s0960-894x(01)80223-7

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