+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chemically induced cell proliferation in liver carcinogenesis

, : Chemically induced cell proliferation in liver carcinogenesis. Progress in Clinical and Biological Research 369: 389-395

Hepatocyte proliferation has been noted in several stages of the hepatocarcinogenic process. Immediately associated with DNA adducts, hepatocyte proliferation clearly has been shown to enhance initiation. The evidence is strong that enhanced cell proliferation, preceeding DNA repair of endogenous and exogenous lesions, thereby results in the fixation of mutagenic events. In contrast to the rather well-established role of hepatocyte proliferation in the initiation phase of carcinogenesis, the role of chemically induced hepatocyte proliferation in liver tumor development is supported by sparse information. Although the available data suggest that chronic cell proliferation in the liver may be associated with tumorigenesis, this information is limited to simple correlations and a relatively small number of chemicals. In the carcinogenic process, another aspect of chemically induced cell proliferation would be direct stimulation of the altered hepatocytes to proliferate and develop tumors rapidly. This latter hypothesized activity is the least well characterized and documented for cell proliferation at this time. Because a quantitative relationship between hepatocyte proliferation and carcinogenic potential has been established for only a few chemicals, general conclusions must await data from correlative studies with other chemicals. Some correlations have been noted, but correlations do not prove cause and effect. The underlying mechanisms of chemically induced cell proliferation must be understood before cause-and-effect relationships between hepatocyte proliferation and enhancement of multiple stages of liver tumor development can be drawn.


PMID: 1946534

Other references

Kogaya, Y., 1984: Electron microscopy and histochemical studies on matrix vesicle mediated-calcification and acidic glycosaminoglycans in early dentinogenesis. Gifu Shika Gakkai Zasshi 11(3): 488-517

Reed, R.K.; Berg, A.; Gjerde, E.A.; Rubin, K., 2001: Control of interstitial fluid pressure: role of beta1-integrins. This review has summarized experiments which show that the connective tissue cells can actively modulate the physical properties of the interstitial matrix so that it becomes an "active" participant in transcapillary fluid exchange and t...

Beck, B., 1980: Europe. Farming in the EEC, Europe's green and expensive land. This review of the current agricultural situation in EC member countries, explains the mechanics of CAP, the differing importance of agriculture to different member countries, distribution of support funds for different products, the UK's fin...

Chong, L.K.; Drury, D.E.J.; Dummer, J.F.; Ghahramani, P.; Schleimer, R.P.; Peachell, P.T., 1997: Protection by dexamethasone of the functional desensitization to beta-2-adrenoceptor-mediated responses in human lung mast cells. 1. The beta-adrenoceptor agonist, isoprenaline, inhibited the IgE-mediated release of histamine from human lung mast cells (HLMC) in a dose-dependent manner. Maximal inhibitory effects were obtained with 0.1 mu-M isoprenaline. However, the inhibit...

Stalke, D., 2012: Dietmar Stalke. Angewandte Chemie 51(39): 9730-9731

Khan, F.D.; Roychowdhury, S.; Gaspari, A.A.; Svensson, C.K., 2006: Immune response to xenobiotics in the skin: from contact sensitivity to drug allergy. Skin is the most frequent target of adverse drug reactions. These cutaneous drug reactions (CDRs) show varied clinical manifestations ranging from mildly discomforting rashes to life-threatening Stevens-Johnson syndrome or toxic epidermal necrolys...

Pavlovic, M.; Udovc, A., 1995: Possibilities of computer supported data use within information management in agriculture. This paper discusses the use of some contemporary computer supported sources of information in agricultural research and extension work.

McCann, S.R.; Gately, K.; Conneally, E.; Lawler, M., 2003: Molecular response to imatinib mesylate following relapse after allogeneic SCT for CML. Blood 101(3): 1200-1201

Jones D.; Spring E., 1973: Formulas for the calculation of the total dose in fractionated radio therapy. Cancer Research 33(11): 3051

Du, F-Tao., 2011: Clinical analysis of interspinous dynamic internal fixation with the Coflex system in treating lumbar degenerative disease. To compare the clinical effects between interspinous dynamic internal fixation with Coflex system and posterior lumbar interbody fusion in treating lumbar degenerative disease. From Jan. 2007 to Jan. 2010, 42 patients with lumbar degenerative dise...