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Dual therapy with doxycycline and ketoprofen compared to doxycycline in the treatment of uncomplicated non-gonococcal urethritis


, : Dual therapy with doxycycline and ketoprofen compared to doxycycline in the treatment of uncomplicated non-gonococcal urethritis. Annals of the Academy of Medicine, Singapore 24(4): 519-522

The aim of this study was to compare a combination of doxycyline and ketoprofen, and doxycycline alone in treating non-gonococcal urethritis (NGU), with particular emphasis on reducing recurrent or persistent disease. Sixty-five men with first episode acute NGU were enrolled between November 1992 and November 1994. The men were randomly assigned to either the doxycycline plus ketoprofen group, group A (doxycycline 100 mg twice daily for 10 days plus ketoprofen 200 mg daily for 10 days, n = 34), or the doxycycline group, group B (100 mg twice daily for 10 days, n = 31). Out of the 65 patients studied, Chlamydia trachomatis was isolated from 9 patients (13.8%), Ureaplasma urealyticum from 6 patients (9.2%) and Mycoplasma hominis from 2 patients (3.1%). At 6 weeks in group A, 16 patients (47%) were cured, one patient had a recurrence (2.9%), and 4 patients had persistent infection (11.8%). Eleven patients defaulted follow-up (32.4%) and 2 patients were dropped from the trial. In contrast, for group B, 13 patients (42%) were cured, 5 patients (16%) had a recurrence, 2 patients (6.5%) had persistent infection and 3 patients (9.7%) were reinfected. Eight patients (25.8%) defaulted follow-up. At 12 weeks, for group A, 14 patients (41.2%) remained cured, one patient (2.9%) had a recurrence, 4 patients (11.8%) had persistent infection and one patient (2.9%) was reinfected. Twelve patients (35.3%) defaulted follow-up. For group B, 8 patients (25.8%) remained cured, 6 patients (19.4%) had recurrence, 2 patients (6.5%) had persistent infection and 5 patients (16.1%) were reinfected. Ten patients (32.2%) defaulted follow-up. There were no statistically significant differences between the two groups except for patients with recurrent NGU where the difference (1 versus 6 patients) was statistically significant (P = 0.019).

US$29.90

PMID: 8849180


Other references

Silberstein, E.B.; Bahr, G.K.; Kattan, J., 1975: Thermographically measured normal skin temperature asymmetry in the human male. The detection of thermal asymmetry may lead to the diagnosis of significant disease states, especially those of a neoplastic or vascular nature. Estimates of acceptable thermal asymmetry have been made; thermal asymmetry has not previously been qu...

Lorenzato, A.; Martino, C.; Dani, N.; Oligschläger, Y.; Ferrero, A.Maria.; Biglia, N.; Calogero, R.; Olivero, M.; D.R.nzo, M.Flavia., 2012: The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C. The cellular apoptosis susceptibility gene CAS/CSE1L is overexpressed in cancer, although it was originally identified as a gene that renders cells vulnerable to apoptotic stimuli. CAS/CSE1L has roles in the nucleocytoplasmic recycling of importin...

Conzelmann, K-Klaus., 2005: Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. A crucial step in murine natural killer (NK) cell development, mediated by bone marrow stromal cells, is the induction of Ly49 and CD94/NKG2 receptor expression. The signals that regulate Ly49 receptor expression are still largely undetermined. It...

McGiff, J.C.; Crowshaw, K.; Terragno, N.A.; Lonigro, A.J., 1970: Renal prostaglandins: possible regulators of the renal actions of pressor hormones. Nature 227(5264): 1255-1257

MacCorquodale, D.W.; Pullum, T.W., 1974: A mathematical model for determining effectiveness of family planning clinics. Studies in Family Planning 5(7): 232-238

Copius Peereboom Stegeman J.H.J.; Van Veen H.A., 1986: Different types of collagen containing vacuoles in uterine fibroblasts showing cyclic variations. Journal of Dental Research 65(SPEC ISSUE): 833

Alam M.; Ashraf M.; Dara M.S.T., 1985: Isolation and quantitative determination of atropine and scopolamine in datura and hyoscyamus seeds. A facile procedure for the isolation, separation and quantitative determination of atropine and scopolamine in the seeds of Daturastramonium and various species of Hyoscyamus is described. A sample is spotted onto a thin-layer of Kieselgel-G. The...

Masouye I.; Salomon D.; Chavaz P.; Carraux P.; Saurat J H., 1989: Keratosis lichenoides chronica no effect of ciclosporin. Dermatologica (Basel) 179(4): 228-229

Keyse S.M.; Tyrrell R.M., 1987: Both near uv radiation and the oxidizing agent hydrogen peroxide induce a 32 kda stress protein in normal human skin fibroblasts. We have analyzed the pattern of protein synthesis in solar near ultraviolet (334 nm, 365 nm) and near visible (405 nm) irradiated normal human skin fibroblasts. Two hours after irradiation we find that one major stress protein of approximately 32...

Sundaresan, V.J.nes, J.1; Ow, D.1; Ausubel, F., 1983: Klebsiella pneumoniae nifA product activates the Rhizobium meliloti nitrogenase promoter Nitrogen fixing bacteria. Nature 2, 301(5902): 728-732