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Effect of acute administration of pyridostigmine and pirenzepine on ACTH, growth hormone and cortisol secretion in Cushings and in obese patients


, : Effect of acute administration of pyridostigmine and pirenzepine on ACTH, growth hormone and cortisol secretion in Cushings and in obese patients. Neuroendocrinology Letters 16(2): 145-150

The effects of pyridostigmine (PD) (120 mg p.o.) and pirenzepine (PZ) (75 mg p.o.) on GH and ACTH/cortisol secretion were studied in 12 obese and 5 Cushing's patients. PD did not alter plasma ACTH and cortisol levels while inducing, in the obese but not in Cushing's patients, a small but appreciable GH rise (p lt 0.05 between GH values in the two groups). PZ was completely ineffective. These data seem to indicate that: a) both in Cushing's and in obese patients there is an impaired central cholinergic neurotransmission, the alteration being more pronounced in the former; b) cholinergic neuroregulation is not crucial for basal ACTH secretion in man.

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