+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of acute administration of pyridostigmine and pirenzepine on ACTH, growth hormone and cortisol secretion in Cushings and in obese patients

, : Effect of acute administration of pyridostigmine and pirenzepine on ACTH, growth hormone and cortisol secretion in Cushings and in obese patients. Neuroendocrinology Letters 16(2): 145-150

The effects of pyridostigmine (PD) (120 mg p.o.) and pirenzepine (PZ) (75 mg p.o.) on GH and ACTH/cortisol secretion were studied in 12 obese and 5 Cushing's patients. PD did not alter plasma ACTH and cortisol levels while inducing, in the obese but not in Cushing's patients, a small but appreciable GH rise (p lt 0.05 between GH values in the two groups). PZ was completely ineffective. These data seem to indicate that: a) both in Cushing's and in obese patients there is an impaired central cholinergic neurotransmission, the alteration being more pronounced in the former; b) cholinergic neuroregulation is not crucial for basal ACTH secretion in man.


Other references

Brignoli, PM.; Chemini, C.; Perini, G.; Scali, V., 1986: Side by side duplication of the epigyne in a wolf spider (Araneae, Lycosidae) from northern Italy. A female Alopecosa albofasciata (Brulle, 1832) with two well developed epigynes placed side by side was collected near Trento, Northern Italy. This case appears to be different from the three other occurrences of this abnormality hitherto known, s...

Uderzo, C.; Colleselli, P.; Dini, G.; Bonetti, F.; Andolina, F.; Bagnulo, S.; Miniero, R.; Rondelli, R.; Balduzzi, A.; Locasciulli, A., 1991: An Italian study comparing allogeneic and autologous BMT in childhood acute lymphoblastic leukemia using HD-vincristine, F-TBI and cyclophosphamide. Bone Marrow Transplantation 7 Suppl 3: 19-21

Kovbas, P.S., 1945: Comparative efficiency of sulfidine used intravenously in the treatment of pneumonia. Klinicheskaia Meditsina 23(6): 74-74

Cuschieri, J.; Bulger, E.; Grinsell, R.; Garcia, I.; Maier, R.V., 2007: Insulin regulates macrophage activation through activin A. Strict control of serum glucose with insulin has been associated with a reduction in the development of multiple organ dysfunction syndrome potentially through alterations in macrophage activation. Although the mechanism responsible for this effec...

Rangachari, K.; Jeyalaxmi, J.; Eswari Pandaranayaka, P.J.; Prasanthi, N.; Sundaresan, P.; Krishnadas, S.R.; Krishnaswamy, S., 2011: Significance of G-X-W motif in the myocilin olfactomedin domain. Journal of Ocular Biology, Diseases, and Informatics 4(4): 154-158

Neumark-Sztainer, D.; Kristal, A.R.; Thornquist, M.D.; Patterson, R.E.; Neuhouser, M.L.; Barnett, M.J.; Rock, C.L.; Cheskin, L.J.; Schreiner, P.; Miller, D.L., 2000: Early adopters of olestra-containing foods: who are they?. The characteristics of people consuming olestra-containing foods when first introduced at a test-marketing site were assessed in 1,007 adults in Indianapolis, Indiana. The subjects participated in a baseline clinic visit and completed at least 2 o...

Ballard, T.O.; Foley, M.E.; Bauman, T.T., 1996: Germination, viability, and protein changes during cold stratification of giant ragweed (Ambrosia trifida L.) seed. The influence of cold stratification on giant ragweed (Ambrosia trifida) seed germination and protein changes occurring during stratification was examined. Giant ragweed seeds were dry after-ripened at 4, 8 and 20 degrees C and cool-moist stratifi...

Seijo Martínez, M.; Castro del Río, M.; Losada Campa, A.; Varela Freijanes, A.; Rodríguez, M., 2000: Chorea as the presenting form of progressive systemic sclerosis. We present an exceptional case of a patient with hemichorea of ischemic origin as a form of presentation of progressive systemic sclerosis. The neurologic complications, both central and peripheral, of this condition are considered infrequent and...

Dai, M.; Hu, Y.; Zhao, Y.; Zhou, D-Xiu., 2007: Regulatory Networks Involving YABBY Genes in Rice Shoot Development. Shoot development is regulated by specific gene expression programs depending on the interplay between transcription factors and growth hormones that function in specific domains of the meristem and lateral organs. Functional relationship between...

Saletan, Leonard T., 1962: Water treatment and brewing. A survey is presented of the purposes and means of treatment of water available to breweries.