+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of serotonergic antagonism on local responses to an acute and selective endothelial trauma in vivo

, : Effect of serotonergic antagonism on local responses to an acute and selective endothelial trauma in vivo. Journal of Cardiovascular Pharmacology 16 Suppl 3: S40-S44

Serotonin is liberated during platelet release reaction. It is concluded from in vitro experiments that serotonin influences both platelet activation and thrombus-induced vasoconstriction. The subject of the present study was to assess the impact of the serotonin2 antagonist naftidrofuryl on both thrombogenesis and thrombus-induced vasoconstriction in vivo. In a hamster cheek pouch, vessels form a rich meshwork, allowing repetitive experiments to obtain intraindividual control measurements. With a contactless photochemical process, endothelial cells can be damaged in vivo. Regularly platelets and the coagulation system are activated and thrombi are formed. In larger arterial vessels local vasoconstriction occurs. Thrombogenesis was induced in arterioles with an inner diameter between 17 and 20 microns. It was monitored by the continuous measurement of blood cell velocity to assess initial hemodynamics and the interval elapsing until perfusion stops. Solvent alone had no effect. Naftidrofuryl was given in clinically relevant dosages of 1, 5, and 20 mg/kg intra-arterially. Even 1 mg/kg showed a significant antithrombotic effect. Efficacy increased in a dose-related manner as well as during the time interval of observation (i.e., 2 h after application). As an established antithrombotic standard, acetylsalicylic acid was applied in dosages of 10 and 100 mg/kg. Both dosages were found to be antithrombotic, but not more effective than comparable dosages of naftidrofuryl. Larger arterioles with an inner diameter of about 50 microns have smooth muscle cells. They constrict during thrombogenesis as a local response to substances released by the thrombus. Topical application of papaverine abolished vasoconstriction. A thromboxane antagonist (EP092) was also effective. Naftidrofuryl reduced the vasoconstriction whereas its solvent was without effect.


PMID: 1369717

DOI: 10.1097/00005344-199006163-00010

Other references

Layer P.; Singer M.V., 1992: Acute pancreatitis definition and etiopathogenesis of acute pancreatitis. Kozuschek, W And K -J Paquet (Ed ) Pankreas: Diagnostik, Therapie; (The Pancreas: Diagnosis, Therapy) 584p S Karger Ag: Basel, Switzerland; New York, New York, Usa Illus 59-66

Roe, B.B., 1978: Professional advertising: ground rules for ethical relations with the communications media. Annals of Thoracic Surgery 26(1): 1-3

Swenson, K.K.; Nissen, M.Jo.; Henly, S.J.; Maybon, L.; Pupkes, J.; Zwicky, K.; Tsai, M.L.; Shapiro, A.C., 2014: Identification of tools to measure changes in musculoskeletal symptoms and physical functioning in women with breast cancer receiving aromatase inhibitors. To estimate and compare responsiveness of standardized self-reported measures of musculoskeletal symptoms (MSSs) and physical functioning (PF) during treatment with aromatase inhibitors (AIs). Prospective, longitudinal study. Park Nicollet Institu...

Nobles, M.M.; Wilding, L.P.; Lin, H.S., 2010: Flow pathways of bromide and brilliant blue FCF tracers in caliche soils. Land use of caliche soils in limestone regions of Texas is increasingly shifting from traditional ranchland to residential and industrial development. However, little information is available on water flow and solute transport through soils of the...

Karkeek, P.Q., 1893: Health-Resorts in the West of England and South Wales. Torquay. Bristol Medico-Chirurgical Journal 11(40): 93-100

Chen, L.H.; Sowell, R.S.; Humphries, E.G., 1976: A simulation model for multiple harvesting of pickling cucumbers. A simulation model for multiple-pick harvesting of pickling cucumbers was developed. This model can be used as a tool to help optimize farm operation in terms of land area, harvest interval and harvesting machinery selection. This model also helps...

Larsen, W.G., 1989: Why is the USA the only country with compulsory cosmetic labeling?. Contact Dermatitis 20(1): 1-2

Tummala, V.; Rao, L.Nageswara.; Vallury, M.Kumar.; Sanapala, A., 2015: A comparative study-efficacy and safety of combined spinal epidural anesthesia versus spinal anesthesia in high-risk geriatric patients for surgeries around the hip joint. Combined spinal epidural anesthesia (CSEA) has a significant advantage by enabling the use of low dose intrathecal local anesthetic, with knowledge that the epidural catheter may be used to extend the block as necessary. CSEA is useful in high-ris...

Fischer, M.H.; Suer, W.J., 1944: Protein as oxidase. A solution of equal parts of alpha -naphthol and p-phenylenediamine hydrochloride is turned blue by solutions of sodium caseinate or sodium lactalbuminate. The reaction rate depends on the quantity of protein present. It is inhibited to a varying...

Chandebois, R., 1971: Mise en evidence du phenomene de cine-phXlaxie dans le syst8me des cellules de type L de la planaire Dugesia subtentaculata.r. C r Seanc Soc Biol, 165: 1323-1326