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Evidence of the fast change of the dominant epitope in hemagglutinin of highly pathogenic H5N1 viruses


, : Evidence of the fast change of the dominant epitope in hemagglutinin of highly pathogenic H5N1 viruses. Veterinary And Agrochemical Research Centre (coda Cerva): Scientific Report 2007: 63

The present study aimed at identifying amino acid changes in the hemagglutinin (HA) of the highly pathogenic A/crested eagle/Belgium/01/2004 (H5N1) isolate, a clade 1 virus that resulted in resistance to Mabs. For this aim, H5 protein-specific MAbs were obtained and used to select H5N1 escape mutants. In addition, the HA analysis and the prediction of the protein structure by molecular homology were performed based on the sequences of those mutants compared with clade1 and 2 viruses.

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