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Exhaled breath condensate biomarkers in COPD


, : Exhaled breath condensate biomarkers in COPD. European Respiratory Journal 32(2): 472-486

Biomarkers in chronic obstructive pulmonary disease may be useful in aiding diagnosis, defining specific phenotypes of disease, monitoring exacerbations and evaluating the effects of drugs. Exhaled breath condensate is a noninvasive means of sampling the airways, allowing biomarkers of airway inflammation and oxidative stress to be measured. In the present review, the use of exhaled breath condensate biomarkers in chronic obstructive pulmonary disease is explored and potential applications in diagnosis, disease phenotyping, exacerbation monitoring and clinical trials are considered. Exhaled breath condensate biomarkers are comprehensively reviewed in terms of method validation, reproducibility, disease specificity and sensitivity to detect changes in airway inflammation.The commonly used exhaled breath condensate methodologies in chronic obstructive pulmonary disease patients are shown to have considerable variability, due to technical issues concerning both sample collection and analysis. Despite these issues, there is still data to support the use of exhaled breath condensate biomarkers for monitoring chronic obstructive pulmonary disease exacerbations and the response to pharmacological intervention. Further improvements to sample collection and analysis methods will improve the sensitivity of these biomarkers. The use of cytokine arrays, mass spectrometry and nuclear magnetic resonance profiling of exhaled breath condensate has opened a new avenue for analysis, as hypothesis generation from such profiling may lead to further selection of biomarkers for specific analysis.

US$19.90

PMID: 18669788

DOI: 10.1183/09031936.00116107


Other references

Dienst, C., 1936: Sodium-potassium antagonism in relation to water metabolism. K salts have a diuretic action which is more marked the lower the Na intake. In large doses K led to a transient increase in serum K and rapid excretion in the urine. Relief was frequently produced by K salts in oedematous states of varying aetiol...

Basu, S.K.; Ghosal, D.K., 1948: A Case of Bacteræmia Caused by iBacterium Alkaligenes Faecalis. Indian Medical Gazette 83(8): 373-374

Miller, B.Ray.; Bezprozvanny, I., 2011: Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium. Huntington's disease (HD) is a noncurable and progressive autosomal-dominant neurodegenerative disorder that results from a polyglutamine expansion in the amino-terminal region of the huntingtin protein. The generation of rodent HD models has...

Bayomy, N.A.; Abdelaziz, E.Z.; Said, M.A.; Badawi, M.S.; El-Bakary, R.H., 2016: Effect of pycnogenol and spirulina on vancomycin-induced renal cortical oxidative stress, apoptosis, and autophagy in adult male albino rat. Vancomycin-induced nephrotoxicity has been reported to occur in 5%-25% of patients who were administered with it. Several natural antioxidants were found to be effective against drug-induced toxicity. We evaluated the possible protective effects o...

Davis, E., 2006: Elizabeth Davis: An interview with Heather Long. Midwifery Today With International Midwife: 30-31

Neal, W.A., 2003: Obese and overweight: a public health epidemic. West Virginia Medical Journal 98(6): 244-244

Garcia M.G.; Dincsoy M.Y.; Balsam D.; Irwin G.A.L.; Chen S Y., 1986: The relationship between weight percentile distribution in newborn infants and bone mineral content. Pediatric Research 20(4 PART 2): 239A

Würthner, K.; Schrader, R.; Demelt, M., 1979: Tangential pendulum irradiation of the thoracic wall with co-60 during radiation therapy of surgically treated cancers of the breast: comparison of measurement and computation methods for irradiation planning. The irradiation technique for tangential pendulum 60-Co-irradiation of the thoracic wall is described, and the possibility of a homogeneous irradiation of the thoracic region of interest by means of individual irradiation planning together with a...

Oduwole, K.O.; Molony, D.C.; Walls, R.J.; Bashir, S.P.; Mulhall, K.J., 2010: Increasing financial burden of revision total knee arthroplasty. We reviewed the peri-operative and financial data of patients who underwent revision total knee arthroplasty in our institution between 1997 and 2006. The aims were to compare difference in cost between aseptic and septic cases and to identify the...

Kusanovic, J.P.; Espinoza, J.; Romero, R.; Gonçalves, L.F.; Nien, J.K.; Soto, E.; Khalek, N.; Camacho, N.; Hendler, I.; Mittal, P.; Friel, L.A.; Gotsch, F.; Erez, O.; Than, N.G.; Mazaki-Tovi, S.; Schoen, M.L.; Hassan, S.S., 2007: Clinical significance of the presence of amniotic fluid 'sludge' in asymptomatic patients at high risk for spontaneous preterm delivery. To determine the clinical significance of the presence of amniotic fluid (AF) 'sludge' among asymptomatic patients at high risk for spontaneous preterm delivery. This retrospective case-control study included 281 patients with (n = 66) o...