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Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

, : Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Research 809(2): 302-306

It has been reported that intraventricular administration of the melanocortin 4 receptor (MC4-R) agonist MT II and antagonist SHU9119 alter food intake. We found that MT II and SHU9119 have extremely potent effects on feeding when injected in the paraventricular nucleus (PVN), a site where MC4-R gene expression is very high. Our finding provides direct evidence that MC4-R signaling is important is mediating food intake and that melanocortin neurons in the PVN exert a tonic inhibition of feeding behavior. Chronic disruption of this inhibitory signal is a possible explanation of the agouti-obesity syndrome.


PMID: 9853124

DOI: 10.1016/s0006-8993(98)00837-3

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