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Initial study on the association of lipoprotein lipase gene polymorphisms with coronary heart disease


, : Initial study on the association of lipoprotein lipase gene polymorphisms with coronary heart disease. Zhonghua Xinxueguanbing Zazhi 26(4): 309-312, Aug

Objective. To explore the association of LPL gene polymorphisms with CHD. Methods. 106 patients in myocardial infarction survivors were analyzed through a case-control study. Results. The conditional logistic regression analysis demonstrated that 5 factors were associated with CHD. The risk factors were smoking, LPL genotype PVU II (- -) and haplotype H+ P-, while high density lipoprotein cholesterol (HDL-C), apolipoprotein A/B (ApoA/B) ratio seemed as protective factors. After controlling the effect of the other variables, OR of LPL genotype PVU II (- -) and haplotype H+ P- were 17.18 and 3.67, while OR of HDL-C, ApoA/B ratio were respectively 0. 14, 0.15 in model A and 0. 04, 0.09 in model B. Conclusion. These results indicated that LPL genotype PVUII (- -) or haplotype H+ P- other than the conventional risk factors were contributing in CHD and that HDL-C, ApoA/B ratio may be the better independent predictors for CHD than the other plasma lipid parameters.

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