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Lymphocytic enterocolitis in patients with 'refractory sprue'


, : Lymphocytic enterocolitis in patients with 'refractory sprue'. JAMA 262(7): 935-937

We describe a patient with refractory sprue with malabsorption, a flat small-bowel biopsy specimen unresponsive to a gluten-free diet, and colonic biopsy specimens consistent with lymphocytic (microscopic) colitis. To investigate further the relation between celiac disease and lymphocytic or collagenous colitis (a similar and possibly related entity), we examined colorectal and small-bowel biopsy specimens in patients indexed histologically as having celiac disease who have been seen at The Johns Hopkins Hospital since 1958. Of 135 indexed patients, 21 had colorectal biopsies. Colorectal biopsy specimens were abnormal in 7 of the 21 patients. Four patients had biopsy specimens resembling lymphocytic colitis, 2 patients had acute colitis, and another patient had both lymphocytic and acute colitis. No patients had collagenous colitis. Three of the patients with lymphocytic colitis and celiac-like changes of the small bowel never responded to a gluten-free diet and may represent a distinctive panintestinal disease for which the term "lymphocytic enterocolitis" with malabsorption is proposed.

US$19.90

PMID: 2754795

DOI: 10.1001/jama.1989.03430070083035


Other references

Warren P.M.; Kirby T.P.; Wraith P.K.; Carson E.R.; Airlie M.A.A.; D.C.rt S.C.; Hill J.E.; Flenley D.C., 1989: Dynamic analysis of the ventilatory response to hypoxia in normal subjects using a two compartment mathematical model. American Review of Respiratory Disease 139(4 PART 2): A228

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Chaikoff, I.L.; Bloom, B.; Stevens, B.P.; Reinhardt, W.O.; Dauben, W.G., 1951: Pentadecanoic acid-5-C14; its absorption and lymphatic transport. Four rats with thoracic duct cannulae were given pentadecanoic acid-5-C14 in maize oil. Lymph was collected and the lipids were extracted and saponified and the free fatty acids obtained. In 22 hr. 78 to 90 per cent. of the administered radioactiv...

Thomas B.; Devi P.U., 1987: Chromosome protection by wr 2721 and mpg in single and combination treatments. The radioprotective action of thiol compounds 2-mercaptopropionylglycine (MPG) and S-2(aminopropylamino)ethyl phosphorothioic acid (WR-2721) was evaluated either alone or in combination on the bone marrow chromosomes of Swiss albino mice after 4.5...

Ramos, Elisa R., 1963: The circumoval precipitin reaction in schisto-somiasis Information for the clinician. The antigen-antibody basis of the circumoval precipitin test is presented with a review of earlier investigations. The test is specific and sensitive enough to be used in tne diagnosis of chronic schistosomiasis and in cases where the worms are in...

Chai, W.; Hamada, H.; Suhara, J.; Horiuchi, C.A., 2001: Biotransformation of (+)- and (-)-camphorquinones by plant cultured cells. Biotransformation of (+)- and (-)-camphorquinones with suspension plant cultured cells of Nicotiana tabacum and Catharanthus roseus was investigated. It was found that the plant cultured cells of N. tabacum and C. roseus reduce stereoselectively t...

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