geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mints, Munc18-interacting proteins in synaptic vesicle exocytosis


, : Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. Journal of Biological Chemistry 272(50): 31459-31464

Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. Mint proteins are detectable only in brain and are composed of an N-terminal sequence that binds Munc18-1, a middle phosphotyrosine-binding domain, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. In brain, Mint proteins are part of a multimeric complex containing Munc18-1 and syntaxin that likely functions as an intermediate in synaptic vesicle docking/fusion. The phosphotyrosine-binding domain specifically binds to phosphatidylinositol phosphates known to be produced during vesicle exocytosis (Hay, J. C., Fisette, P. L., Jenkins, G. H., Fukami, K., Takonawa, T., Anderson, R. A., and Martin, T. F. J. (1995) Nature 374, 173-177). Our data suggest a model whereby local production of phosphatidylinositol phosphates may trigger the binding of vesicles to the active zone via the Mint.Munc18-1 complex in conjunction with syntaxin 1.

US$19.90

PMID: 9395480

DOI: 10.1016/s0168-0102(98)81871-3


Other references

Yim, A.P.C., 2011: Invited commentary. Annals of Thoracic Surgery 91(1): 243-243

Ovsova G.V., 1971: Effect of ruelene on cholin esterase activity and morphological composition of the blood of experimental animals. Trudy Instituta Kraevoi Patologii Akademii Nauk Kazakhskoi SSR 22: 48-52

Anstey, K.J.; Windsor, T.D.; Rodgers, B.; Jorm, A.F.; Christensen, H., 2005: Lower cognitive test scores observed in alcohol abstainers are associated with demographic, personality, and biological factors: the PATH Through Life Project. Aims To identify variables that explain the association between alcohol abstention and cognitive performance. We hypothesized that demographic and personality variables would be important for explaining the association in all age cohorts, but that...

Dehghan-Nayeri, N.; Bayat, F.; Salehi, T.; Faghihzadeh, S., 2014: The effectiveness of risk management program on pediatric nurses' medication error. Medication therapy is one of the most complex and high-risk clinical processes that nurses deal with. Medication error is the most common type of error that brings about damage and death to patients, especially pediatric ones. However, these error...

Maier, L.J.; Wunderli, M.D.; Vonmoos, M.; Römmelt, A.T.; Baumgartner, M.R.; Seifritz, E.; Schaub, M.P.; Quednow, B.B., 2016: Pharmacological Cognitive Enhancement in Healthy Individuals: A Compensation for Cognitive Deficits or a Question of Personality?. The ongoing bioethical debate on pharmacological cognitive enhancement (PCE) in healthy individuals is often legitimated by the assumption that PCE will widely spread and become desirable for the general public in the near future. This assumption...

Leland, H.V.; Scudder, B.C., 1990: Trace elements in Corbicula fluminea from the San Joaquin River, California. (i) Trace element concentrations in soft tissue of the benthic bivalve, Corbicula fluminea, from the San Joaquin River and its major tributaries were examined during the primary irrigation season in relation to the spatial variation in concentrati...

Pascal, M., 2008: Commentary: Our next challenge in heatwave prevention. International Journal of Epidemiology 37(6): 1365-1366

Catania, A.; Caimi, G., 1992: The erythrocyte membrane: the interrelations between lipids, proteins and the dynamic properties. The erythrocyte membrane, a lipidic-proteic structure, conserves its architecture thanks to interactions that involve the protein-SH-groups and enzymatic activities that keep the phospholipid asymmetry stable. This peculiar organization is essenti...

Hawkes, A.P.; Roy, J.; Stacey-Scott, N.; Joy, J.E.A.; Bogdan, G., 2009: Health and safety issues relating to Maine's fishing industry. The Maine Agricultural Safety and Health Program performed a needs assessment to determine the health and safety concerns of Maine's fishing community. Information for the assessment was obtained from clinicians, focus groups of wives of fish...

Hargreaves, J.A., 1919: Sinistral Limnaea pereger Mull. and its progeny. Journal of Conchology Leeds, 16 55-57