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Octahydronaphthoquinolizines, a new biologically active tetracyclic ring system

, : Octahydronaphthoquinolizines, a new biologically active tetracyclic ring system. Tetrahedron Letters 34(13): 2067-2070

Unsubstituted and methoxy-substituted octahydronaphthoquinolizines, examples of new tetracyclic ring system, have been synthesized in three steps from corresponding 2-tetralones. The various diastereomers of each OHNQ have been separated and characterized by X-ray crystallography and NMR spectroscopy. These compounds have been shown to have activity at selected neurorecepter binding sites.


DOI: 10.1016/s0040-4039(00)60347-7

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