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Protective effects of adeno-associated viral gene transfer of BDNF on the hippocampal neurons


, : Protective effects of adeno-associated viral gene transfer of BDNF on the hippocampal neurons. Chinese Journal Of Immunology: 12, 1100-1102

Objective: To investigate the effective mechanism for transfection of rat brain derived neurotrophic factor (BDNF) gene by recombinant adeno-associated virus in the cultured hippocampal neurons. Methods: rAAV-BDNF was injected into the serum free-induced neurons. DAPI, PI and Actin stain was performed to measure the apoptosis cells and morphogenesis of the cells. Results: After the gene transfer, the survival rate of the serum free-induced neurons was increased by 65%.

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