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Protective effects of adeno-associated viral gene transfer of BDNF on the hippocampal neurons

, : Protective effects of adeno-associated viral gene transfer of BDNF on the hippocampal neurons. Chinese Journal Of Immunology: 12, 1100-1102

Objective: To investigate the effective mechanism for transfection of rat brain derived neurotrophic factor (BDNF) gene by recombinant adeno-associated virus in the cultured hippocampal neurons. Methods: rAAV-BDNF was injected into the serum free-induced neurons. DAPI, PI and Actin stain was performed to measure the apoptosis cells and morphogenesis of the cells. Results: After the gene transfer, the survival rate of the serum free-induced neurons was increased by 65%.


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Lezon, T.R.; Banavar, J.R.; Cieplak, M.; Maritan, A.; Fedoroff, N.V., 2006: Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns. We describe a method based on the principle of entropy maximization to identify the gene interaction network with the highest probability of giving rise to experimentally observed transcript profiles. In its simplest form, the method yields the pa...